Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

6.0K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.0K
Cancer02:18

Cancer

50.7K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
50.7K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.2K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.2K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

5.1K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.1K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

7.1K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.1K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring regional and sociodemographic disparities associated with unenrollment for the disease management program for type 2 Diabetes Mellitus using Bayesian spatial modelling.

Research in health services & regions·2024
Same author

Early clinical trial unit tumor board: a real-world experience in a national cancer network.

Journal of cancer research and clinical oncology·2023
Same author

In-vitro model to mimic T cell subset change in human PDAC organoid co-culture.

Journal of cancer research and clinical oncology·2023
Same author

Preservation of the round ligament to accommodate transient portal hypertension after major hepatectomy.

Langenbeck's archives of surgery·2022
Same author

[Lay version of the 2018 EULAR recommendations for physical activity in people with inflammatory arthritis and osteoarthritis : Translation into German and linguistic validation in German-speaking countries with people affected].

Zeitschrift fur Rheumatologie·2021
Same author

Influence of Klebsiella pneumoniae and quinolone treatment on prognosis in patients with pancreatic cancer.

The British journal of surgery·2021
Same journal

Itaconate in cancer immunity: Evidence, ambiguities, and translational barriers.

Trends in cancer·2026
Same journal

Patient-derived organoids in hematologic malignancies: Fidelity and translation beyond animals.

Trends in cancer·2026
Same journal

Precision neuro-oncology for children: Time to gear up!

Trends in cancer·2026
Same journal

Multi-omics analysis of extracellular vesicle cargo in cancer.

Trends in cancer·2026
Same journal

An immunological panacea for cancer-related cachexia.

Trends in cancer·2026
Same journal

Beyond one gene, one target: Next-generation precision oncology.

Trends in cancer·2026
See all related articles

Related Experiment Video

Updated: Oct 13, 2025

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

19.8K

Cancer catecholamine conundrum.

H Wackerhage1, J F Christensen2, M Ilmer3

  • 1Technical University of Munich, Department of Sport & Health Science, Georg-Brauchle Ring 60-62, 80992 Munich, Germany.

Trends in Cancer
|November 15, 2021
PubMed
Summary
This summary is machine-generated.

Catecholamines can inhibit or promote cancer, a confusing effect termed the cancer catecholamine conundrum. Understanding this requires studying adrenergic receptor variations and cell-specific impacts to aid cancer patients.

Keywords:
adrenergic receptorscatecholaminesexercisestress

More Related Videos

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

23.7K
Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

1.8K

Related Experiment Videos

Last Updated: Oct 13, 2025

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

19.8K
A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

23.7K
Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

1.8K

Area of Science:

  • Oncology
  • Pharmacology
  • Cell Biology

Background:

  • Catecholamines, influenced by exercise, stress, and drugs, play a complex role in cancer.
  • Existing research presents conflicting findings on catecholamines' effects in cancer, creating a 'cancer catecholamine conundrum'.

Purpose of the Study:

  • To explore the variable effects of catecholamines in cancer.
  • To investigate the underlying mechanisms contributing to the cancer catecholamine conundrum.

Main Methods:

  • Review of existing literature on exercise, psychosocial stress, and drug impacts on catecholamines in cancer.
  • Analysis of potential factors contributing to variable catecholamine effects, including adrenergic receptor isoforms and cell-specific signaling.

Main Results:

  • Exercise studies generally indicate catecholamines are cancer-inhibiting.
  • Cancer stress studies often report opposite, cancer-promoting effects.
  • Beta-blocker studies show inconsistent outcomes, highlighting the complexity.

Conclusions:

  • The variable effects of catecholamines in cancer are potentially explained by diverse adrenergic receptor expression and differential impacts on cancer cells, immune cells, and endothelial cells.
  • Further research is crucial to elucidate these mechanisms for therapeutic applications in cancer treatment.