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Mast cell involvement in interstitial cystitis.

W L Lynes1, S D Flynn, L D Shortliffe

  • 1Division of Urology, Stanford University School of Medicine, Palo Alto, California.

The Journal of Urology
|October 1, 1987
PubMed
Summary
This summary is machine-generated.

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Interstitial cystitis involves mast cells, not eosinophils. Degranulated mast cells correlate with bladder damage and treatment response in interstitial cystitis patients.

Area of Science:

  • Urology
  • Pathology
  • Immunology

Background:

  • Interstitial cystitis (IC) is a chronic bladder condition with unknown etiology.
  • Mast cells and eosinophils are implicated in inflammatory conditions, including IC.

Purpose of the Study:

  • To investigate the association between mast cell and eosinophil density, mediator levels, and clinical/histological features of interstitial cystitis.
  • To determine the role of mast cells and eosinophils in the inflammatory process of IC.

Main Methods:

  • Prospective study involving bladder biopsies from IC and control patients.
  • Quantification of intact and degranulated mast cells and eosinophils.
  • Measurement of bladder tissue histamine, urinary prostaglandin E2, and serum/urinary major basic protein.

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Main Results:

  • Significant correlation found between detrusor mast cell density (especially degranulated) and epithelial loss, inflammation, ulceration, pyuria, and treatment response in IC.
  • Elevated bladder histamine and urinary prostaglandin E2 levels in IC patients.
  • No significant difference in eosinophil density between IC and control groups; low levels of major basic protein observed.

Conclusions:

  • Mast cell degranulation is strongly linked to the inflammatory pathology and clinical presentation of interstitial cystitis.
  • Eosinophils do not appear to play a significant role in the pathogenesis of interstitial cystitis based on this study.