Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Leaky Scanning02:28

Leaky Scanning

5.3K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.3K
Ribosome Profiling02:24

Ribosome Profiling

3.7K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
3.7K
Improving Translational Accuracy02:07

Improving Translational Accuracy

12.0K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
12.0K
Termination of Translation01:44

Termination of Translation

5.9K
5.9K
Proofreading01:31

Proofreading

7.0K
Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore,  it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
Errors During Replication are Corrected by the DNA Polymerase...
7.0K
Translational Regulation01:29

Translational Regulation

260
Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
260

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mobile Health Assessment of Traumatic Dental Injuries Using Smartphone-Acquired Photographs: A Multicenter Diagnostic Accuracy Study.

Telemedicine journal and e-health : the official journal of the American Telemedicine Association·2024
Same author

Temperamental and Neuropsychological Predictors for Major League Pro-Baseball Success.

Sports health·2024
Same author

Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios in Preoperative Differential Diagnosis of Benign, Borderline, and Malignant Ovarian Tumors.

Journal of clinical medicine·2022
Same author

Surgical Treatment of Mandible Fracture Using Unsintered Hydroxyapatite/Poly L-Lactide Composite Fixation System.

The Journal of craniofacial surgery·2019
Same author

A comparative study of intraoral versus retromandibular approach in the management of subcondylar fracture.

BMC surgery·2019
Same author

Significance of Intratumoral Fibrosis in Clear Cell Renal Cell Carcinoma.

Journal of pathology and translational medicine·2018
Same journal

The impact of translation modality on user experience: an eye-tracking study of the Microsoft Word user interface.

Machine translation : MT·2021
Same journal

A review of the state-of-the-art in automatic post-editing.

Machine translation : MT·2021
Same journal

A roadmap to neural automatic post-editing: an empirical approach.

Machine translation : MT·2020
Same journal

An error analysis for image-based multi-modal neural machine translation.

Machine translation : MT·2019
Same journal

A Conjoint Analysis Framework for Evaluating User Preferences in Machine Translation.

Machine translation : MT·2014
See all related articles

Related Experiment Video

Updated: Oct 13, 2025

De novo Identification of Actively Translated Open Reading Frames with Ribosome Profiling Data
08:23

De novo Identification of Actively Translated Open Reading Frames with Ribosome Profiling Data

Published on: February 18, 2022

3.8K

Read, spot and translate.

Lucia Specia1, Josiah Wang1, Sun Jae Lee2

  • 1Imperial College London, London, UK.

Machine Translation : MT
|November 15, 2021
PubMed
Summary
This summary is machine-generated.

We introduce novel multimodal machine translation (MMT) methods using object-based referential grounding in the source language. These approaches significantly improve translation accuracy compared to existing MMT models.

Keywords:
Multimodal machine learningMultimodal machine translation

More Related Videos

Universal Screening for Prevention of Reading, Writing, and Math Disabilities in Spanish
14:43

Universal Screening for Prevention of Reading, Writing, and Math Disabilities in Spanish

Published on: July 18, 2020

8.2K
Analysis of Translation Initiation During Stress Conditions by Polysome Profiling
10:59

Analysis of Translation Initiation During Stress Conditions by Polysome Profiling

Published on: May 19, 2014

18.5K

Related Experiment Videos

Last Updated: Oct 13, 2025

De novo Identification of Actively Translated Open Reading Frames with Ribosome Profiling Data
08:23

De novo Identification of Actively Translated Open Reading Frames with Ribosome Profiling Data

Published on: February 18, 2022

3.8K
Universal Screening for Prevention of Reading, Writing, and Math Disabilities in Spanish
14:43

Universal Screening for Prevention of Reading, Writing, and Math Disabilities in Spanish

Published on: July 18, 2020

8.2K
Analysis of Translation Initiation During Stress Conditions by Polysome Profiling
10:59

Analysis of Translation Initiation During Stress Conditions by Polysome Profiling

Published on: May 19, 2014

18.5K

Area of Science:

  • Natural Language Processing
  • Computer Vision
  • Machine Learning

Background:

  • Multimodal machine translation (MMT) aims to enhance translation by incorporating visual information.
  • Existing MMT models often use whole images or abstract regions for visual grounding, which can be suboptimal.

Purpose of the Study:

  • To propose and evaluate novel multimodal machine translation (MMT) approaches that leverage object-level referential grounding.
  • To investigate two distinct referential grounding strategies: implicit and explicit grounding.

Main Methods:

  • Developed MMT models that ground source language words to specific image objects.
  • Implemented implicit grounding, where visual grounding and translation are learned jointly.
  • Implemented explicit grounding, where visual grounding is performed independently and then used to guide translation.
  • Conducted experiments on the Multi30K dataset for English-German, English-French, and English-Czech language pairs.

Main Results:

  • Referential grounding models focusing on objects demonstrated superior performance over existing MMT approaches.
  • Both implicit and explicit grounding methods showed significant improvements in translation quality.
  • Evaluations using automatic metrics and human judgment confirmed the effectiveness of the proposed methods.

Conclusions:

  • Object-level referential grounding in the source language is a more effective strategy for MMT than previous methods.
  • The proposed implicit and explicit grounding approaches offer viable pathways for advancing MMT systems.
  • This work highlights the importance of fine-grained visual grounding for improving cross-modal translation.