Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Innovation in experimental teaching practice based on miniature mass spectrometer： from mass spectrometry principles to applications].

Se pu = Chinese journal of chromatography·2026
Same author

Metal-driven nanoassembly of hexahistidine-tagged melittin enables superior phytopathogen biofilm degradation with attenuated toxicity.

Journal of nanobiotechnology·2026
Same author

Gut microbiota-derived lysine phenylacetylation impairs mitochondrial function and is alleviated by SIRT3.

Cell metabolism·2026
Same author

Rapid On-Site Analysis of Psychotropic Drugs in Dried Blood Spots by Capillary-in-Capillary Electrospray Ionization (DBS-CC-ESI) Miniature Mass Spectrometry.

Journal of the American Society for Mass Spectrometry·2026
Same author

Cross-kingdom metabolic interactions govern Candida albicans overgrowth and colitis progression.

Cell host & microbe·2026
Same author

The 1-hour plasma glucose as a specific marker for early-phase insulin secretory defects in young adults with obesity.

Diabetes research and clinical practice·2026

Related Experiment Video

Updated: Oct 13, 2025

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
08:23

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

11.3K

Altered Spontaneous Brain Activity Patterns and Functional Connectivity in Adults With Intermittent Exotropia: A

Xueying He1, Jie Hong2, Qian Wang1

  • 1Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Frontiers in Neuroscience
|November 15, 2021
PubMed
Summary

This study reveals altered brain activity and functional connectivity in intermittent exotropia (IXT) patients. These changes in brain regions related to vision and eye movement offer new insights into IXT

Keywords:
amplitude of low-frequency fluctuationsfunctional connectivityintermittent exotropiaresting-state functional MRIspontaneous activity

More Related Videos

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
08:36

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

7.4K
Resting-State Connectivity and Neuroimaging of Prefrontal Cortex Activity During a Block-Design Yoga Asana Practice Using fNIRS
07:56

Resting-State Connectivity and Neuroimaging of Prefrontal Cortex Activity During a Block-Design Yoga Asana Practice Using fNIRS

Published on: June 24, 2025

454

Related Experiment Videos

Last Updated: Oct 13, 2025

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
08:23

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

11.3K
Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
08:36

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

7.4K
Resting-State Connectivity and Neuroimaging of Prefrontal Cortex Activity During a Block-Design Yoga Asana Practice Using fNIRS
07:56

Resting-State Connectivity and Neuroimaging of Prefrontal Cortex Activity During a Block-Design Yoga Asana Practice Using fNIRS

Published on: June 24, 2025

454

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Medical Imaging

Background:

  • Intermittent exotropia (IXT) is a common strabismus with unclear neurological underpinnings.
  • Understanding the brain's functional alterations in IXT is crucial for developing targeted treatments.

Purpose of the Study:

  • To investigate brain functional changes in IXT patients using resting-state functional magnetic resonance imaging (rs-fMRI).
  • To analyze amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) in IXT.
  • To correlate brain activity with clinical features of IXT.

Main Methods:

  • rs-fMRI scans were acquired from 26 IXT patients and 22 healthy controls (HCs).
  • Amplitude of low-frequency fluctuation (ALFF) and fractional ALFF (fALFF) were analyzed in slow 4 and slow 5 bands.
  • Functional connectivity (FC) was calculated and compared between groups. Correlations with clinical data were assessed.

Main Results:

  • IXT patients showed increased ALFF/fALFF in the right angular gyrus, supramarginal gyrus, inferior parietal lobule, precentral gyrus, and bilateral inferior frontal gyri.
  • Decreased ALFF/fALFF was observed in the right precuneus, left middle occipital gyrus, and postcentral gyrus in IXT patients.
  • Widespread increased FC was found in IXT, particularly involving vision and eye movement-related areas. No decreased FC was observed.

Conclusions:

  • IXT patients exhibit distinct patterns of aberrant intrinsic brain activity and functional connectivity.
  • These findings highlight the involvement of vision and eye movement networks in the pathophysiology of IXT.
  • This research advances the understanding of neurological mechanisms underlying visual and oculomotor deficits in IXT.