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Plant Secondary Metabolite Transporters: Diversity, Functionality, and Their Modulation
Panchsheela Nogia1, Pratap Kumar Pati1
1Department of Biotechnology, Guru Nanak Dev University, Amritsar, India.
Frontiers in Plant Science
|November 15, 2021
Summary
Plant secondary metabolite (SM) transporters are vital for plant functions but poorly understood. This review details recent advances in identifying and characterizing these transporters, offering insights for metabolic engineering and crop improvement.
Area of Science:
- Plant biology
- Biochemistry
- Molecular biology
Background:
- Secondary metabolites (SMs) are essential for plant growth, development, defense, and survival, requiring specific transport mechanisms.
- The transport mechanisms of SMs are significantly less understood compared to primary metabolites, creating a knowledge gap.
- Understanding SM transporters is crucial for meeting the demand for bioactive compounds in herbal medicine and for crop improvement.
Purpose of the Study:
- To review recent advancements in the field of plant secondary metabolite transporters.
- To provide insights into various characterized transporter families (ABC, MATE, PUP, NPF), their functions, and structures.
- To explore the concept and potential applications of 'Transporter Engineering' for enhanced metabolite production and crop improvement.
Main Methods:
- Literature review focusing on plant SM transporters discovered in the past two decades.
- Analysis of diverse transporter families, including ABC, MATE, PUP, and NPF.
- Discussion of identification, characterization, regulation, and modulation strategies for SM transporters.
Main Results:
- Detailed insights into fully or partially characterized SM transporters from ABC, MATE, PUP, and NPF families.
- Information on transporter functionalities, structural aspects, and regulatory parameters.
- A novel perspective on 'Transporter Engineering' with potential applications in plant stress tolerance, SM accumulation, and anti-nutritional compound removal.
Conclusions:
- A better understanding of plant SM transporters is essential for metabolic engineering and enhancing bioactive compound production.
- Transporter engineering offers a viable strategy for improving plant stress tolerance, increasing SM accumulation, and removing anti-nutritional compounds.
- This review provides a roadmap for identifying and understanding transporters as targets for future engineering efforts in crop improvement programs.
Keywords:
ABCMATENPFPUPmetabolite transportersecondary metabolitesystemic metabolic engineeringtransporter engineeringMore Related Videos
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