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Updated: Oct 13, 2025
Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
Published on: February 9, 2011
Prevalence of methicillin-resistant Staphylococcus aureus in a tertiary hospital in Nepal
P Pradhan1, P Rajbhandari1, S B Nagaraja2
1Department of Medical Microbiology and Immunology, Patan Academy of Health Sciences, Lalitpur, Nepal.
Setting:
Patan Hospital, Lalitpur, Nepal.
Objectives:
To describe 1) the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) and its antibiotic sensitivity pattern; 2) the demographic and clinical characteristics associated with MRSA infections; and 3) the treatment outcomes of in-patients with MRSA infection among patients with S. aureus infection between January 2018 and December 2020.
Design:
This was a cross-sectional study using electronic and paper-based hospital records of patients with S. aureus infection.
Results:
Of the 1,804 patients with S. aureus infection, 1,027 patients (57%, 95% CI 55-59) had MRSA. The MRSA were susceptible to vancomycin (100%), linezolid (96%), doxycycline (96%), chloramphenicol (86%) and cotrimoxazole (70%), and resistant to erythromycin (68%), clindamycin (56%), gentamycin (58%), ciprofloxacin (92%) and ofloxacin (91%). The prevalence of MRSA was higher in 2019, among out-patients, and in respiratory samples, and lower in blood samples. Of the 142 in-patients with MRSA, 93% had a successful clinical outcome (cured/improved).
Conclusion:
More than 50% of patients with S. aureus infection had MRSA that were resistant to commonly available antibiotics. This calls for strengthening surveil-lance and good infection control practices in this hospital.
Insights
Methicillin-resistant Staphylococcus aureus (MRSA) infections are common, with over 50% of Staphylococcus aureus infections being MRSA. Many MRSA strains show resistance to common antibiotics, highlighting the need for improved surveillance and infection control.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Public Health
Background:
- Staphylococcus aureus is a common pathogen.
- Methicillin-resistant Staphylococcus aureus (MRSA) is a significant cause of healthcare-associated infections.
- Understanding MRSA prevalence and resistance patterns is crucial for effective treatment and control.
Purpose of the Study:
- To determine the prevalence of MRSA and its antibiotic sensitivity among Staphylococcus aureus infections at Patan Hospital, Nepal.
- To identify demographic and clinical factors associated with MRSA infections.
- To evaluate treatment outcomes for inpatients with MRSA infections.
Main Methods:
- A cross-sectional study was conducted using hospital records from January 2018 to December 2020.
- Data on 1,804 patients with Staphylococcus aureus infections were analyzed.
- Antibiotic susceptibility testing results were reviewed for MRSA isolates.
Main Results:
- MRSA accounted for 57% of Staphylococcus aureus infections (1,027 out of 1,804 patients).
- MRSA showed high susceptibility to vancomycin (100%) and linezolid (96%), but significant resistance to erythromycin (68%) and ciprofloxacin (92%).
- In-patients with MRSA infections had a 93% successful clinical outcome rate.
Conclusions:
- Over half of Staphylococcus aureus infections at this institution were MRSA.
- High rates of resistance to commonly used antibiotics necessitate enhanced surveillance and infection control measures.
- Effective treatment outcomes were observed in the majority of MRSA in-patients.
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