Related Experiment Video
Updated: Oct 13, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
Published on: May 30, 2025
Long Non-Coding RNA: A Potential Strategy for the Diagnosis and Treatment of Colorectal Cancer
Shanshan Chen1, Yi Fang1,2, Lingyu Sun1,2
1The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, China.
Abstract:
Colorectal cancer (CRC), being one of the most commonly diagnosed cancers worldwide, endangers human health. Because the pathological mechanism of CRC is not fully understood, there are many challenges in the prevention, diagnosis, and treatment of this disease. Long non-coding RNAs (lncRNAs) have recently drawn great attention for their potential roles in the different stages of CRC formation, invasion, and progression, including regulation of molecular signaling pathways, apoptosis, autophagy, angiogenesis, tumor metabolism, immunological responses, cell cycle, and epithelial-mesenchymal transition (EMT). This review aims to discuss the potential mechanisms of several oncogenic lncRNAs, as well as several suppressor lncRNAs, in CRC occurrence and development to aid in the discovery of new methods for CRC diagnosis, treatment, and prognosis assessment.
Related Concept Videos
lncRNA - Long Non-coding RNAs
Non-LTR Retrotransposons
Types of RNA
RNA Performs Diverse...
Experimental RNAi

