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The Scavenger Receptor MARCO Expressed by Tumor-Associated Macrophages Are Highly Associated With Poor Pancreatic

Bian Shi1, Junfeng Chu2, Tao Huang3

  • 1Department of Integrated Traditional Chinese and Western Medicine, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China.

Frontiers in Oncology
|November 15, 2021
PubMed

Insights

High expression of MARCO and CD163 in pancreatic cancer tissues indicates poor prognosis. Targeting MARCO may offer a new immunotherapy strategy for pancreatic cancer patients.

Area of Science:

  • Immunology
  • Oncology
  • Pathology

Background:

  • Macrophage-targeting therapies are promising for cancer immunotherapy.
  • MARCO deficiency inhibits pancreatic cancer progression in mice, but its role in human patients is unknown.

Purpose of the Study:

  • To investigate the role of MARCO and CD163 in pancreatic cancer prognosis.
  • To analyze tumor-associated macrophage (TAM) changes in pancreatic cancer tissues.

Main Methods:

  • Analysis of The Cancer Genome Atlas database for TAM-related changes.
  • Immunohistochemical analysis of MARCO and CD163 expression in surgical pancreatic cancer tissues (n=65).
  • Correlation of marker expression with clinical data and patient survival.

Main Results:

  • Pancreatic cancer tissues showed enrichment of M2 macrophages and increased expression of pro-tumor markers, including MARCO and CD163.
  • MARCO expression is notably high in pancreatic cancer compared to other solid tumors.
  • High MARCO and CD163 expression correlated with worse disease-free and overall survival, independent of other factors.

Conclusions:

  • Elevated MARCO and CD163 expression in pancreatic cancer tissues serves as a negative prognostic marker.
  • Targeting MARCO presents a potential novel therapeutic strategy for pancreatic cancer.
Keywords:
CD163MARCOpancreatic cancerprognosistumor-associated macrophage

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