Treatment Experience of 210 Pediatric Patients With Extraordinary Daytime Urinary Frequency: A Prospective Study
Yan Li1, Ying Zhang2, Chao Liu3
1Pediatric Center, Qilu Hospital of Shandong University, Qingdao, China.
Insights
Lactulose effectively treats pediatric extraordinary daytime urinary frequency (PEDUF), showing higher response rates than counseling alone. This study suggests lactulose is a valuable treatment for children with PEDUF and constipation.
Area of Science:
- Pediatric Urology
- Gastroenterology
- Pharmacology
Background:
- Pediatric extraordinary daytime urinary frequency (PEDUF) lacks established treatments.
- Lactulose is used for constipation but its efficacy for PEDUF is unstudied.
- Constipation is common in families of children with PEDUF.
Purpose of the Study:
- To evaluate the efficacy of non-drug treatment versus oral lactulose for PEDUF.
- To compare counseling, lactulose, and combination therapy in managing PEDUF.
Main Methods:
- Prospective study of 210 pediatric patients with PEDUF.
- Randomized groups: counseling, lactulose, or combination therapy.
- Therapeutic effect defined as >10% decrease in urination frequency.
Main Results:
- Lactulose and combination therapy showed significantly higher response rates (90.0% and 91.4%) than counseling (61.4%).
- High prevalence of constipation (82.4%) observed in families of patients.
- No significant difference between lactulose monotherapy and combination therapy.
Conclusions:
- Constipation is highly prevalent in children with PEDUF.
- Oral lactulose demonstrates a high therapeutic response rate for PEDUF.
- Lactulose represents a promising therapeutic strategy for PEDUF, superior to counseling alone.
Abstract:
Background: Lactulose can be used to manage chronic constipation and children who are withholding their bowel movements, but no studies are available regarding lactulose to treat pediatric extraordinary daytime urinary frequency (PEDUF). To explore the benefits of different therapeutic regimens (non-drug treatment vs. oral lactulose) in patients with PEDUF. Methods: This prospective study included PEDUF patients admitted to the Pediatric Center of Qilu Hospital of Shandong University (Qingdao) from January 2015 to December 2019. The patients randomized received non-drug treatment (counseling), drug treatment (lactulose), or combination therapy. A therapeutic effect was defined by a decrease of>10% of the urination frequency. Results: A total of 210 patients were included. They were 5.9 ± 0.4 years. There were 98 boys and 112 girls. Among the 210 patients, 82.4% (173/210) of their family members reported symptoms of constipation. Among the three groups, the response rate was 61.4% (43/70) in the non-drug treatment group, 90.0% (63/70) in the drug treatment group, and 91.4% (64/70) in the combination therapy group (P < 0.0001). Conclusion: The frequency of constipation in children with PEDUF is high. The use of a laxative, like lactulose, might achieve a high therapeutic response rate in children with PEDUF, higher than counseling alone. That might represent a valuable therapeutic strategy for PEDUF.
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