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Updated: Aug 13, 2026

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Development of a Refined Protocol for Trans-scleral Subretinal Transplantation of Human Retinal Pigment Epithelial Cells into Rat Eyes
Published on: August 12, 2017
Retinal transplants can drive a pupillary reflex in host rat brains
1Department of Neurobiology, University of Pittsburgh, School of Medicine, PA 15261.
Abstract:
Retinae taken from embryonic rats were transplanted over the midbrain of neonatal rats, from whom one eye had been removed. After 5 months, the optic nerve of the remaining eye was cut, and the transplant was exposed. Illumination of the transplant caused pupilloconstriction of the host eye, a response abolished by damaging the transplant. Thus neural transplants are capable of driving specific reflexes in response to natural stimuli.

