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Predictive Value of HFA-PEFF Score in Patients With Heart Failure With Preserved Ejection Fraction
Yuxi Sun1, Jinping Si1, Jiaxin Li1
1Heart Failure and Structural Cardiology Ward, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Frontiers in Cardiovascular Medicine
|November 15, 2021
Summary
The HFA-PEFF score aids in diagnosing heart failure with preserved ejection fraction (HFpEF) and predicting mortality. Higher scores correlate with increased all-cause mortality risk in HFpEF patients.
Area of Science:
- Cardiology
- Clinical Medicine
- Medical Diagnostics
Background:
- Heart failure with preserved ejection fraction (HFpEF) presents diagnostic challenges.
- Prognostic tools for HFpEF patients are limited.
- The HFA-PEFF score is a proposed diagnostic tool for HFpEF.
Purpose of the Study:
- To evaluate the HFA-PEFF score's ability to predict all-cause mortality in patients with HFpEF.
- To assess the prognostic value of the HFA-PEFF score in HFpEF.
Main Methods:
- Retrospective observational study of 358 HFpEF patients.
- Patients categorized into low (0-2), intermediate (3-4), and high (5-6) HFA-PEFF score groups.
- Primary outcome: all-cause mortality over a mean follow-up of 26.9 months.
Main Results:
- Higher HFA-PEFF scores were associated with increased all-cause mortality.
- Multivariate Cox regression identified HFA-PEFF score as an independent predictor of mortality (HR: 1.314, P=0.039).
- ROC analysis showed the HFA-PEFF score effectively predicts mortality (AUC 0.726, P=0.000) with a cut-off of 3.5.
Conclusions:
- The HFA-PEFF score is valuable for both diagnosing HFpEF and predicting patient prognosis.
- The HFA-PEFF score effectively predicts all-cause mortality in HFpEF patients.
- Higher HFA-PEFF scores indicate a greater risk of mortality in HFpEF.
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