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Updated: Oct 13, 2025

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques
Published on: June 11, 2019
Clinical Application of Dynamic Contrast Enhanced Perfusion Imaging by Cardiovascular Magnetic Resonance
Russell Franks1, Sven Plein1,2, Amedeo Chiribiri1
1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
Insights
Cardiovascular magnetic resonance (CMR) perfusion imaging offers a radiation-free method to assess coronary artery disease by evaluating myocardial blood flow. This technique is valuable for diagnosing and managing patients with chronic coronary syndromes.
Area of Science:
- Cardiology
- Medical Imaging
- Radiology
Background:
- Coronary artery disease (CAD) significantly impacts myocardial blood flow.
- Non-invasive myocardial perfusion imaging is crucial for detecting CAD.
- Cardiovascular magnetic resonance (CMR) offers high resolution and avoids ionizing radiation.
Purpose of the Study:
- To provide an overview of CMR perfusion imaging.
- To discuss its clinical applications in chronic coronary syndromes.
- To highlight advancements and challenges in the field.
Main Methods:
- Dynamic contrast-enhanced CMR perfusion imaging.
- Assessment of myocardial blood flow.
- Risk stratification in patients with CAD.
Main Results:
- CMR perfusion imaging is a validated tool for CAD assessment.
- It is recommended by international guidelines.
- Quantitative perfusion analysis is an emerging area.
Conclusions:
- CMR perfusion imaging is a powerful, non-invasive tool for evaluating CAD.
- It excels in assessing chronic coronary syndromes.
- Future directions include advanced quantitative analysis.
Abstract:
Functionally significant coronary artery disease impairs myocardial blood flow and can be detected non-invasively by myocardial perfusion imaging. While multiple myocardial perfusion imaging modalities exist, the high spatial and temporal resolution of cardiovascular magnetic resonance (CMR), combined with its freedom from ionising radiation make it an attractive option. Dynamic contrast enhanced CMR perfusion imaging has become a well-validated non-invasive tool for the assessment and risk stratification of patients with coronary artery disease and is recommended by international guidelines. This article presents an overview of CMR perfusion imaging and its clinical application, with a focus on chronic coronary syndromes, highlighting its strengths and challenges, and discusses recent advances, including the emerging role of quantitative perfusion analysis.
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