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Introduction of Two-Dose Mumps-Containing Vaccine into Routine Immunization Schedule in Quzhou, China, Using

Zhiying Yin1, Canjie Zheng1, Quanjun Fang1

  • 1Quzhou Center for Disease Control and Prevention, Quzhou, 324000 Zhejiang, China.

Journal of Immunology Research
|November 15, 2021
PubMed

Insights

Two doses of the measles-mumps-rubella (MMR) vaccine offer better protection against mumps than one dose. This study suggests revising diagnostic criteria and implementing two-dose MMR vaccination for improved mumps control.

Area of Science:

  • Epidemiology
  • Vaccinology
  • Virology

Background:

  • Mumps incidence is rising in vaccinated children, indicating waning immunity or vaccine effectiveness issues.
  • The measles-mumps-rubella (MMR) vaccine is crucial for mumps prevention, but one-dose efficacy is questioned.
  • Understanding the impact of different mumps-containing vaccine (MuCV) doses is vital for public health strategies.

Purpose of the Study:

  • To analyze the effectiveness of varying mumps-containing vaccine (MuCV) doses against mumps.
  • To identify risk factors and protective factors for mumps infection in vaccinated children.
  • To inform recommendations for mumps vaccination schedules and diagnostic criteria in China.

Main Methods:

  • Retrospective analysis of 909 clinically diagnosed mumps cases in children vaccinated with different MuCV doses.
  • Application of Kaplan-Meier survival analysis and Cox-proportional hazard models.
  • Inclusion of data from children born between 2006-2010, vaccinated in Quzhou (2006-2018).

Main Results:

  • Kaplan-Meier curves showed no significant difference in cumulative hazard between males and females.
  • Lower mumps hazard was observed in children vaccinated with two-dose MuCV, born in 2006, and infected after supplementary immunization activities (SIA).
  • Cox regression confirmed that onset after SIA, birth year 2006, and two-dose MuCV vaccination were protective factors against mumps.

Conclusions:

  • The study highlights the need for revised mumps diagnostic criteria, recommending RT-PCR as the standard in China.
  • A two-dose MMR vaccination schedule is suggested for routine immunization.
  • Prevaccination screening before booster immunizations in vaccinated populations is recommended to enhance mumps control.

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