Circulating fibrocyte level in children with cystic fibrosis
Pınar Aslan Yaşar1, Mehmet Köse2, Serife Erdem3,4
1Department of Pediatrics, Erciyes University, Kayseri, Turkey.
Insights
Circulating fibrocytes are elevated in cystic fibrosis (CF) patients. This study found higher fibrocyte counts in CF individuals compared to controls, with lower counts in CF patients showing positive CT scan results.
Area of Science:
- Immunology
- Pulmonology
- Cell Biology
Background:
- Cystic Fibrosis (CF) is a genetic disorder affecting multiple organs, primarily the lungs.
- Fibrocytes are circulating progenitor cells with roles in inflammation and tissue repair.
- Understanding fibrocyte dynamics in CF may offer insights into disease mechanisms.
Purpose of the Study:
- To quantify circulating fibrocyte levels in cystic fibrosis patients.
- To compare fibrocyte counts during stable and exacerbated CF conditions.
- To explore correlations between fibrocytes and lung function/imaging in CF.
Main Methods:
- Inclusion of 39 CF patients and 20 healthy controls.
- Categorization into CF, exacerbated CF, and healthy control groups.
- Measurement of circulating fibrocyte counts.
- Evaluation of pulmonary function tests (PFTs) and high-resolution computed tomography (HRCT) findings.
Main Results:
- Significantly higher circulating fibrocyte counts were observed in CF patients compared to exacerbated CF and control groups.
- No correlation was found between PFT parameters (FEV1, FVC) and circulating fibrocyte counts.
- CF patients with positive HRCT findings exhibited statistically lower circulating fibrocyte counts.
Conclusions:
- Circulating fibrocyte levels are elevated in the peripheral blood of cystic fibrosis patients.
- Fibrocyte levels may not directly correlate with PFT measures in CF.
- Lower fibrocyte counts in CF patients with positive HRCT suggest a complex role in disease progression.
Background:
This study aimed to evaluate circulating fibrocyte levels in cystic fibrosis (CF) patients during stable and exacerbation periods of the condition.
Methods:
The study group consisted of 39 patients diagnosed with CF and 20 healthy controls. Individuals included in the study were divided into three groups: CF, CF exacerbated, and a healthy control group. Their circulating fibrocyte levels were compared. Findings from a pulmonary function test and high-resolution computed tomography of the lung were evaluated and compared.
Results:
The circulating fibrocyte count was found to be significantly higher in patients with CF compared with the exacerbated and control groups. No correlation was found between the forced expiratory volume in 1 s and forced vital capacity values in the pulmonary function test and the circulating fibrocyte count. The circulating fibrocyte count in patients (in the CF group) with positive findings in the high-resolution computed tomography was statistically significantly lower.
Conclusions:
The circulating fibrocyte level in the peripheral blood of the patients with CF was increased.
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