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Studies on gastric bicarbonate secretion in man.
1Department of Surgery II, Sahlgren's Hospital, Gothenburg University, Sweden.
Acta Chirurgica Scandinavica. Supplementum
|January 1, 1987
Summary
A new method accurately measures gastric bicarbonate secretion. Vagal stimulation increases secretion in healthy subjects, while surgery alters basal secretion in ulcer patients.
Area of Science:
- Gastroenterology
- Physiology
Background:
- Gastric bicarbonate secretion is crucial for mucosal protection.
- Understanding its regulation is key for treating acid-related disorders.
Purpose of the Study:
- To develop and validate a method for measuring human gastric bicarbonate secretion.
- To investigate the regulation of basal and stimulated gastric bicarbonate secretion.
Main Methods:
- Developed a gastric perfusion system with continuous pH and PCO2 monitoring.
- Minimized saliva contamination and accounted for swallowed saliva.
- Stimulated secretion via sham feeding (vagal) and fundic distension.
Main Results:
- Sham feeding significantly increased gastric bicarbonate secretion in healthy subjects (p < 0.001).
- This vagal response was mediated by muscarinic receptors.
- Duodenal ulcer patients showed altered basal and post-vagotomy secretion patterns.
Conclusions:
- The developed method reliably measures gastric bicarbonate secretion.
- Vagal stimulation and fundic distension are significant regulators of gastric bicarbonate output.
- Proximal gastric vagotomy impacts basal, but not vagally stimulated, bicarbonate secretion.