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Related Experiment Video

Updated: Oct 13, 2025

Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells

Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells

Published on: October 19, 2021

Targeting T cell metabolism for immunotherapy.

Jie Gao¹, Yanbo Liu¹, Jian Wei²

¹Zhongshan Hospital, Fudan University, Shanghai, China.

Journal of Leukocyte Biology

|November 15, 2021

Summary

T cells are crucial for fighting tumors. Targeting their nutrient use and metabolic pathways can enhance their anti-tumor activity, offering a new strategy for cancer immunotherapy.

Keywords:

T cell antitumor immunity immunotherapy metabolic reprogramming

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Published on: December 26, 2019

Area of Science:

Immunology
Metabolic pathways
Cancer research

Background:

T cells are vital for antitumor immunity.
Nutrient metabolism regulates T cell numbers and function.
Metabolic reprogramming is a hallmark of cancer cells.

Purpose of the Study:

To review the relationship between T cell metabolism and function.
To highlight the metabolic state of tumor-infiltrating T cells.
To identify key metabolic pathways influencing T cell antitumor activity.

Main Methods:

Literature review of studies on T cell metabolism and antitumor immunity.
Analysis of metabolic pathways relevant to T cell function in the tumor microenvironment.
Synthesis of current knowledge on targeting T cell metabolism for cancer immunotherapy.

Main Results:

T cell metabolism significantly impacts their ability to combat tumors.
Tumor-infiltrating T cells exhibit distinct metabolic profiles.
Specific metabolic pathways are critical for maintaining T cell antitumor function.

Conclusions:

Metabolic interventions represent a promising strategy to enhance T cell-mediated antitumor immunity.
Targeting T cell metabolism can augment the efficacy of existing cancer immunotherapies.
Further research into T cell metabolic reprogramming holds potential for novel cancer treatments.