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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

961
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
961
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

748
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
748

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Related Experiment Video

Updated: Oct 13, 2025

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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The Frontloading Fields Study (FFS): Detecting Changes in Mean Deviation in Glaucoma Using Multiple Visual Field

Jack Phu1,2, Michael Kalloniatis1,2

  • 1Centre for Eye Health, University of New South Wales, Kensington, NSW, Australia.

Translational Vision Science & Technology
|November 15, 2021
PubMed
Summary
This summary is machine-generated.

Performing two visual field tests per visit, especially every six months, significantly improves early glaucoma detection and reduces the time to identify mean deviation changes. This practical approach enhances diagnostic accuracy compared to single tests or less frequent follow-ups.

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Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Diagnostic Imaging

Background:

  • Early detection of glaucoma is crucial for preventing vision loss.
  • Mean deviation (MD) changes over time are key indicators of glaucoma progression.
  • Optimizing the number of visual field tests per visit can enhance diagnostic efficiency.

Purpose of the Study:

  • To evaluate the impact of varying numbers of visual field tests per visit on detecting mean deviation changes in early glaucoma.
  • To identify an optimal, practical strategy for maximizing the detection of glaucoma progression.

Main Methods:

  • A simulation model using intrasession and intersession visual field data from glaucoma patients.
  • Modeled 10,000 progressing and 10,000 non-progressing simulated patients over time.
  • Assessed variables included follow-up intervals, reliability rates, and 1-4 visual field tests per visit.

Main Results:

  • Two visual field tests per visit significantly increased detection rates (99%-99.8%) compared to one test (34.7%-76.3%) at 2 years.
  • Two tests reduced the time to detection (3-4 visits vs. 6-10 visits) and identified less severe MD changes (-4 dB vs. -10 dB).
  • Six-month follow-up intervals showed less severe mean deviation loss compared to 1- or 2-year intervals.

Conclusions:

  • Performing two visual field tests per visit, particularly with the SITA-Faster algorithm every six months, is a practical and effective strategy.
  • This approach substantially improves the detection rate of mean deviation changes in early glaucoma.
  • The findings provide guidance for optimizing clinical visit protocols to enhance glaucoma monitoring.