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Racial Differences in Urine Testing of Febrile Young Children Presenting to Pediatric Hospitals
Sriram Ramgopal1,2, Nichell Tidwell3, Nader Shaikh4
1Division of Emergency Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. sramgopal@luriechildrens.org.
Insights
Black children received less urine testing for urinary tract infections (UTIs) in emergency departments, but this did not lead to more missed diagnoses or revisits. Further research is needed to understand these disparities in pediatric UTI care.
Area of Science:
- Pediatric Emergency Medicine
- Infectious Diseases
- Health Equity
Background:
- Historical practice guidelines suggested lower urinary tract infection (UTI) risk in Black children.
- Race-based clinical decisions raise concerns about potential disparities in healthcare.
- Investigating disparities in diagnostic testing for febrile young children is crucial.
Purpose of the Study:
- To examine urine testing rates (urinalysis and/or urine culture) among young febrile children in the emergency department (ED) by race/ethnicity.
- To assess the association between race/ethnicity and UTI diagnosis and 7-day revisits.
- To identify potential missed diagnoses related to race-based testing variations.
Main Methods:
- A multicenter retrospective cohort study included 734,730 children aged 2-24 months with fever across 26 US EDs (2009-2019).
- Longitudinal testing trends were evaluated using a generalized linear mixed-effects model.
- Associations of race/ethnicity with testing, UTI diagnoses, and revisits were characterized.
Main Results:
- Black children constituted 24.1% of the cohort and showed lower urine testing rates (23.4%) compared to White (31.7%) and Hispanic (33.9%) children.
- Black patients had significantly lower adjusted odds of receiving urine testing (OR 0.70; 95% CI 0.69-0.71).
- Among tested patients, UTI diagnosis rates were 2.4% for Black children versus 3.3% for White children. Return visits within 7 days were slightly higher for Black children who received testing on the index visit (8.5%) compared to those who did not (7.6%).
Conclusions:
- Black patients experienced lower rates of urine testing and UTI diagnoses in the ED setting.
- These disparities in testing were not linked to increased rates of missed diagnoses or unscheduled return visits.
- Further investigation is warranted to understand and address the observed racial disparities in pediatric UTI diagnostic practices.
Introduction:
Dating back to 2011, practice guidelines considered Black race a factor associated with lower risk of urinary tract infection (UTI). Race-based clinical decisions raise concerns about potential treatment disparities. We investigate urine testing (urinalysis and/or urine culture) among young febrile children in the emergency department (ED), revisits, and potential missed diagnoses by race/ethnicity.
Methods:
We performed a multicenter retrospective cohort study of children 2-24 months evaluated in 26 US EDs from 2009 to 2019 with a fever diagnosis. We evaluated longitudinal testing trends, constructed a generalized linear mixed-effects model to identify the association of race/ethnicity with testing, and characterized UTI diagnoses and ≤ 7-day revisits.
Results:
Of 734,730 included patients, 24.1% were Black. Variation in urine testing was observed by patient race/ethnicity (23.4% Black, 31.7% White, 33.9% Hispanic, 30.0% other race). Relative differences in testing persisted over time. Black patients had lower adjusted odds of testing (0.70, 95% confidence interval [CI] 0.69-0.71). Among patients with urine testing, 2.4% (95% CI 2.3-2.6%) of Black and 3.3% (95% CI 3.1-3.4%) of White patients were diagnosed with UTI. Among Black patients with urine testing on the index visit, 8.5% (95% CI 8.2-8.8%) had return visits compared to 7.6% (95% CI 7.5-7.8%) among those without urine testing on index visit. Among patients with urine testing on revisit, UTI diagnosis was similar by race/ethnicity.
Conclusion:
Black patients had lower rates of urine testing and UTI diagnoses relative to other racial/ethnic groups. This was not associated with higher rates of missed diagnoses or unscheduled return visits.
Related Concept Videos
Urine Studies I: Urinalysis
Urine Studies II: Urine Culture and Sensitivity Test
Pharmacokinetics in Pediatric Patients: Drug Excretion
Pharmacokinetics in Pediatric Patients: Drug Distribution
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
Drug Dosing: Infants and Children

