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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

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Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
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Related Experiment Video

Updated: Oct 13, 2025

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
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Recent approaches towards bone tissue engineering.

F Raquel Maia1, Ana R Bastos1, Joaquim M Oliveira1

  • 13B's Research Group, I3Bs-Research Institute on Biomaterials, Biodegradables and Biomimetics of University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal; ICVS/3B's PT Government Associate Laboratory, Braga, Guimarães, Portugal.

Bone
|November 15, 2021
PubMed
Summary
This summary is machine-generated.

Bone tissue engineering utilizes scaffold-based and scaffold-free methods to mimic bone. Recent advances focus on biomaterials, fabrication, and vascularization for improved bone regeneration.

Keywords:
3D bioprinting3D printingBone tissue engineeringScaffoldsSpheroidsVascularized strategies

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Bone tissue engineering aims to regenerate bone defects, overcoming limitations of traditional bone grafts.
  • Current strategies involve combining biomaterials, cells, and bioactive cues with advanced fabrication techniques.
  • Mimicking native bone structure and vascularization remains a significant challenge.

Purpose of the Study:

  • To provide an overview of recent biomimetic scaffold-based and scaffold-free approaches in bone tissue engineering.
  • To highlight the materials and fabrication methods employed in these strategies.
  • To discuss emerging biomimetic vascularized approaches.

Main Methods:

  • Review of scaffold-based strategies using diverse biomaterials and fabrication techniques.
  • Analysis of scaffold-free approaches, focusing on endochondral ossification mimicry.
  • Examination of pre-vascularized scaffolds and cellular aggregates for enhanced vascularization.

Main Results:

  • Scaffold-based strategies increasingly utilize innovative biomaterials and fabrication methods to improve bone mimicry.
  • Scaffold-free methods aim to replicate natural bone formation processes, particularly endochondral ossification.
  • Development of pre-vascularized constructs is a key trend for addressing bone's high vascularization.

Conclusions:

  • Biomimetic approaches, both scaffold-based and scaffold-free, are advancing bone tissue engineering.
  • Material selection and fabrication techniques are crucial for achieving bone-like properties.
  • Vascularization strategies are essential for the successful integration and function of engineered bone grafts.