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Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma
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Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma

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NCCN Guidelines® Insights: B-Cell Lymphomas, Version 5.2021

Andrew D Zelenetz1, Leo I Gordon2, Julie E Chang3

  • 1Memorial Sloan Kettering Cancer Center.

Journal of the National Comprehensive Cancer Network : JNCCN
|November 15, 2021
PubMed

Insights

Novel targeted therapies, including small molecule inhibitors and CAR T-cell therapy, offer new treatment options for relapsed/refractory B-cell non-Hodgkin lymphomas. These advancements are reflected in updated NCCN Guidelines for B-Cell Lymphomas.

Area of Science:

  • Oncology
  • Hematology
  • Molecular Biology

Background:

  • Significant advancements in understanding B-cell non-Hodgkin lymphomas' molecular pathogenesis over the past decade.
  • Emergence of targeted therapies addressing specific molecular pathways and proteins involved in lymphoma development.

Purpose of the Study:

  • To highlight novel targeted therapy options for relapsed/refractory (R/R) B-cell non-Hodgkin lymphomas.
  • To present updates to the NCCN Guidelines for B-Cell Lymphomas based on new therapeutic developments.

Main Methods:

  • Review of recent molecular and clinical research in B-cell non-Hodgkin lymphomas.
  • Inclusion of new targeted agents in NCCN Guidelines, including small molecule inhibitors and CAR T-cell therapy.

Main Results:

  • Identification of novel targeted therapies such as kinase inhibitors, antibody-drug conjugates, and protein-targeting small molecules (CD-19, EZH2, XPO-1).
  • Anti-CD19 CAR T-cell therapy approved for R/R diffuse large B-cell lymphoma and emerging for R/R follicular lymphoma and mantle cell lymphoma.

Conclusions:

  • New targeted therapies represent significant progress in treating R/R B-cell non-Hodgkin lymphomas.
  • Updated NCCN Guidelines incorporate these novel treatment strategies, offering improved options for patients with R/R disease.

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