Related Experiment Video
Updated: Oct 13, 2025
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
13.3K
Metastatic Prostate Cancer: Treatment Options
Vérane Achard1,2, Paul Martin Putora3,4, Aurelius Omlin5
1Department of Radiation Oncology, Geneva University Hospital, Geneva, Switzerland.
Oncology
|November 15, 2021
Summary
New treatments significantly improve survival for metastatic prostate cancer (PCa). Combining therapies upfront or sequencing them effectively is crucial for optimizing outcomes in hormone-sensitive and castration-resistant PCa.
Area of Science:
- Oncology
- Urology
- Medical Therapeutics
Background:
- Metastatic prostate cancer (PCa) historically has poor overall survival (OS).
- Androgen deprivation therapy (ADT) was the standard, but patients often progress to castration-resistant disease.
Purpose of the Study:
- To review the evolving treatment landscape for metastatic prostate cancer.
- To discuss the efficacy of novel agents and therapeutic sequencing.
Main Methods:
- Review of current clinical evidence and therapeutic guidelines.
- Discussion of systemic therapies and radiotherapy in the metastatic setting.
Main Results:
- Upfront combination therapy with docetaxel or novel hormonal agents improves OS in metastatic hormone-sensitive PCa.
- Therapeutic agents are also effective in the castration-resistant phase, raising questions about optimal sequencing.
Conclusions:
- Novel agents have improved outcomes, shifting the treatment paradigm for metastatic PCa.
- Choosing the best therapy combination and sequence requires careful consideration of patient comorbidities and preferences.
- Radiotherapy is emerging as an option in the oligometastatic setting.
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