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Updated: Oct 13, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
THE ROLE OF HUMAN COMPLEMENT PROTEIN FACTOR B AND FACTORP/PROPERDIN IN HIV-ASSOCIATED PRE-ECLAMPSIA
Phumelele Kikine1, Yazira Pillay1, Thajasvarie Naicker1
1Department of Optics and Imaging, University of Kwa-Zulu Natal, Durban, South Africa.
Objectives:
This study seeks to discover how the concentration of complement proteins, factors B and P are affected in HIV-associated PE.
Methods:
This study included 72 pregnant women: 36 preeclamptic and 36 normotensive. Serum concentrations of factors B and P were measured using a Bioplex immunoassay.
Results:
A significant decrease of factor B in the HIV+ compared to the HIV- group was noted. No significant difference across all groups for both analytes was observed.
Conclusion:
Our results suggest the alternative pathway (AP) is inhibited by HIV evading immune detection. The AP is not excessively activated in PE during the third trimester.
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