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Aggregation induced emission materials for tissue imaging.

Madan R Biradar1, Rajesh S Bhosale2, Sidhanath Vishwanath Bhosale1

  • 1Polymers and Functional Materials Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India.

Progress in Molecular Biology and Translational Science
|November 16, 2021
PubMed
Summary

Aggregation-Induced Emission (AIE) probes offer advanced molecular and nanoparticle architectures for superior tissue imaging. This review highlights AIEgens for in vivo and in vitro bioimaging, focusing on infrared windows for deep, high-resolution imaging.

Keywords:
Aggregation induced emissionFluorescenceLuminescent nanomaterialMicroscopic techniquesPolymersTissue imaging

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Optical Imaging

Background:

  • Aggregation-Induced Emission (AIE) materials exhibit unique photophysical properties.
  • AIE molecular architectures, nanoparticles (NPs), and conjugated polymer (CP) probes show promise in bioimaging.
  • Current advancements focus on enhancing AIE probes for detailed tissue visualization.

Purpose of the Study:

  • To summarize recent progress in AIE-based molecular, NP, and CP probes for tissue imaging.
  • To highlight the application of AIEgens in both in vivo and in vitro bioimaging.
  • To discuss the use of infrared windows for improved deep-tissue imaging resolution.

Main Methods:

  • Review of AIE molecular architectures, NPs, and CPs for bioimaging.
  • Focus on microscopic techniques for morphological and molecular information.
  • Analysis of infrared windows for enhanced fluorescence microscopy in tissues.

Main Results:

  • AIE probes demonstrate outstanding performance in bioimaging applications.
  • Microscopic techniques provide in-depth morphological and molecular insights.
  • Infrared windows enable deep penetration and high-resolution tissue imaging.

Conclusions:

  • AIE-based probes are powerful tools for advanced tissue imaging.
  • The development of AIEgens offers significant opportunities in sensing and biomedical fields.
  • Future challenges in AIEgens for tissue imaging are identified.