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Patented AIE materials for biomedical applications.

Sopan M Wagalgave1, Shailesh S Birajdar1, Jotiram N Malegaonkar1

  • 1Polymers and Functional Materials Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India.

Progress in Molecular Biology and Translational Science
|November 16, 2021
PubMed
Summary

Patented aggregation-induced emission (AIE) materials, like tetraphenylethylene (TPE), are crucial for biological and medicinal applications. These AIE materials offer enhanced fluorescence for advanced bioimaging and biotechnology uses.

Keywords:
AIEBioimagingBiosensingCell trackingIntracellularPatent

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Area of Science:

  • Materials Science
  • Biotechnology
  • Organic Chemistry

Background:

  • Aggregation-Induced Emission (AIE) is a rapidly growing field with diverse organic building blocks.
  • AIE materials exhibit enhanced fluorescence upon aggregation, making them attractive for various applications.
  • Patented AIE materials are increasingly important in biological and biotechnological research.

Purpose of the Study:

  • To review patented Aggregation-Induced Emission (AIE) materials.
  • To highlight the utilization of AIE materials in biological, medicinal, and biotechnology fields.
  • To explore the potential of AIE chromophores in bioimaging and biomedical applications.

Main Methods:

  • Review of patented AIE materials and their applications.
  • Discussion of AIE chromophores like tetraphenylethylene (TPE).
  • Compilation of representative patented examples for bioimaging and medicinal imaging.

Main Results:

  • AIE chromophores, including TPE, are vital fluorescent emissive bioactive materials.
  • These materials are extensively used as bioprobes for cellular imaging, diagnostics, and therapy.
  • Significant fluorescence enhancement is observed when AIE materials are imaged in cellular environments.

Conclusions:

  • Patented AIE chromophores demonstrate substantial potential for bioimaging and biomedical applications.
  • The development of novel AIE materials continues to expand their utility in diagnostics and therapeutics.
  • AIE technology offers promising avenues for advancements in medical imaging and drug delivery.