Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultra-small luminescent copper nanocluster-catalyzed C-S cross coupling reactions: the effect of ligand substituents in modulating catalytic efficiency.

Nanoscale·2026
Same author

Dancing to the tune of the light regime: from perception to secondary metabolite biosynthesis in plants.

Critical reviews in biotechnology·2026
Same author

Photoswitchable Small Molecules for Cancer Therapeutics: Mechanisms, Advances, and Challenges.

Chemistry, an Asian journal·2026
Same author

Biological and Catalytic Potential of Vanadium Complexes of <i>N</i>-Methyl-<i>N</i>-phenylhydrazinecarbothioamide Based ONS Donor Ligands.

Inorganic chemistry·2025
Same author

A mitochondria-targeted green light-activatable binuclear ruthenium(II) dithiocarbamate complex for synergistic type I/II photodynamic therapy.

Dalton transactions (Cambridge, England : 2003)·2025
Same author

Redox-Inactive Terpyridine Zn(II)-Azide Complexes for Photodynamic and Photoactivatable Chemotherapy.

Journal of medicinal chemistry·2025

Related Experiment Video

Updated: Oct 13, 2025

An In Vitro Approach to Photodynamic Therapy
04:53

An In Vitro Approach to Photodynamic Therapy

Published on: August 17, 2018

8.9K

AIE material for photodynamic therapy.

Vishal Saini1, V Venkatesh1

  • 1Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, India.

Progress in Molecular Biology and Translational Science
|November 16, 2021
PubMed
Summary
This summary is machine-generated.

Aggregation-induced emission (AIE) materials offer a novel approach to photodynamic therapy (PDT) by overcoming traditional limitations. These AIE-based photosensitizers (AIE-PSs) enhance cancer treatment through improved imaging and therapeutic efficacy.

Keywords:
AIE-PS nanoparticlesAggregation-induced emission fluorogensAggregation-induced emission photosensitizerCombination therapyFluorescencePhotodynamic therapyPolymer based AIE-PSProdrug strategyReactive oxygen speciesSinglet oxygenTargeted AIE-PSTwo-photon absorbance

More Related Videos

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
11:04

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Published on: January 13, 2023

3.3K
Rose Bengal-Mediated Photodynamic Therapy to Inhibit Candida albicans
04:48

Rose Bengal-Mediated Photodynamic Therapy to Inhibit Candida albicans

Published on: March 24, 2022

3.4K

Related Experiment Videos

Last Updated: Oct 13, 2025

An In Vitro Approach to Photodynamic Therapy
04:53

An In Vitro Approach to Photodynamic Therapy

Published on: August 17, 2018

8.9K
An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
11:04

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Published on: January 13, 2023

3.3K
Rose Bengal-Mediated Photodynamic Therapy to Inhibit Candida albicans
04:48

Rose Bengal-Mediated Photodynamic Therapy to Inhibit Candida albicans

Published on: March 24, 2022

3.4K

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Photochemistry

Background:

  • Photodynamic therapy (PDT) is a promising cancer treatment due to its non-invasive nature and minimal side effects.
  • Traditional photosensitizers (PSs) suffer from aggregation-induced quenching (ACQ), limiting their effectiveness.
  • Aggregation-induced emission (AIE) materials overcome ACQ, showing enhanced fluorescence and reactive oxygen species (ROS) generation in aggregated states.

Purpose of the Study:

  • To review strategies for developing AIE-based photosensitizers (AIE-PSs) for advanced PDT applications.
  • To explore the design of targeted AIE-PSs for selective cancer cell destruction.
  • To discuss the potential of nanoparticle-based AIE-PSs for combination therapies and overcoming drug resistance.

Main Methods:

  • Synthesis of small molecule, metal complex, polymer, and nanoparticle-based AIE-PSs.
  • Incorporation of two-photon absorbance (TPA) properties into AIE-PSs.
  • Conjugation of targeting peptides to AIE-PSs for enhanced cellular specificity.

Main Results:

  • AIEgens exhibit superior fluorescence and ROS production in aggregated states compared to ACQ materials.
  • Various AIE-PS architectures (small molecules, complexes, polymers, nanoparticles) have been successfully developed for PDT.
  • Targeted AIE-PSs demonstrate selective cancer cell targeting, and nanoparticle-based combination therapies show synergistic anticancer effects.

Conclusions:

  • AIE-PSs represent a significant advancement in PDT, offering improved imaging and therapeutic outcomes.
  • Rational design of AIE-PSs, including targeting and combination strategies, is crucial for overcoming challenges in cancer treatment.
  • Further research into AIE-PSs holds promise for developing more effective and less toxic cancer therapies.