Related Experiment Video
Updated: Oct 13, 2025

Author Spotlight: Investigating Bacteriophage-Induced Immune Responses in Gnotobiotic Mice
Published on: January 26, 2024
Bacteriophages and their potential for treatment of gastrointestinal diseases
Yi Duan1,2, Ry Young3,4,5, Bernd Schnabl6,7,8
1Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Abstract:
Although bacteriophages have been overshadowed as therapeutic agents by antibiotics for decades, the emergence of multidrug-resistant bacteria and a better understanding of the role of the gut microbiota in human health and disease have brought them back into focus. In this Perspective, we briefly introduce basic phage biology and summarize recent discoveries about phages in relation to their role in the gut microbiota and gastrointestinal diseases, such as inflammatory bowel disease and chronic liver disease. In addition, we review preclinical studies and clinical trials of phage therapy for enteric disease and explore current challenges and potential future directions.
More Related Videos
Related Concept Videos
Lytic Cycle of Bacteriophages
DNA Bacteriophages
Lysogenic Cycle of Bacteriophages
Microorganisms in Medicine and Therapeutics
Viral Replication: Lysogenic Cycle
Biological Methods for Microbial Control

