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Targeting long non coding RNA by natural products: Implications for cancer therapy

Mina Homayoonfal1, Zatollah Asemi1, Bahman Yousefi2,3

  • 1Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, I.R. Iran.

Critical Reviews in Food Science and Nutrition
|November 16, 2021
PubMed

Insights

Phytochemicals can regulate long non-coding RNAs (lncRNAs), offering a novel approach to combat cancer. This review explores their potential in cancer treatment and prevention by modulating lncRNA activity.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Cancer incidence and mortality continue to rise globally despite therapeutic advancements.
  • Many cancers are diagnosed late or develop resistance to conventional treatments like chemotherapy and radiotherapy.
  • Long non-coding RNAs (lncRNAs) play crucial roles in cancer development and progression.

Approach:

  • This review investigates the impact of various phytochemicals on lncRNA regulation in human cancers.
  • It evaluates the potential of phytochemicals to inhibit oncogenic lncRNAs and stimulate tumor suppressor lncRNAs.
  • The study assesses phytochemicals as an innovative strategy to enhance cancer treatment and prevention.

Key Points:

  • Phytochemicals demonstrate inhibitory effects on oncogenic lncRNAs, crucial for cancer cell growth, proliferation, metastasis, and invasion.
  • Certain phytochemicals can stimulate tumor suppressor lncRNAs, counteracting cancer development.
  • Phytochemicals may increase cancer cell sensitivity to standard therapies.

Conclusions:

  • Phytochemicals represent a promising avenue for cancer therapy and prevention by targeting lncRNA pathways.
  • Further research into phytochemical-lncRNA interactions could lead to novel, effective cancer treatment strategies.
  • Integrating phytochemicals with existing therapies may improve patient outcomes and overcome treatment resistance.
Keywords:
Apoptosiscancer therapylong non-coding RNA (lncRNA)metastasisnatural productphytochemicalproliferation

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