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Published on: July 1, 2015
[Objective parameters of auditory function in premature infants in the first year of life after taking ototoxic
M R Bogomilsky1, Yu S Ishanova1, I N Dyakonova1
1Pirogov Russian National Research Medical University, Moscow, Russia.
Insights
Ototoxic antibiotics in premature infants may delay auditory maturation, as indicated by changes in distortion product otoacoustic emissions (DPOAE) and short-latency evoked potentials (SLEP) during the first year of life.
Area of Science:
- Neonatal audiology
- Otoacoustic emissions
- Evoked potentials
Background:
- Premature infants are vulnerable to hearing damage from ototoxic medications.
- Early auditory assessment is crucial for identifying potential hearing impairments.
Purpose of the Study:
- To compare auditory function in premature infants exposed to ototoxic antibiotics versus those not exposed.
- To evaluate the timing of auditory system maturation using DPOAE and SLEP.
Main Methods:
- Auditory function assessed in 145 premature infants using DPOAE, SLEP, and tympanometry.
- Statistical analysis performed using Statgraphics Centurion XV.
Main Results:
- Cochlear responses (DPOAE) in infants with ototoxic therapy showed delayed maturation until 6 months.
- Delayed maturation of auditory pathways (SLEP) was observed in infants receiving ototoxic antibiotics in the first month of life.
Conclusions:
- Ototoxic antibiotic exposure impacts auditory development timing in premature infants.
- Established audiological monitoring protocols for premature infants post-ototoxicosis.
Objective:
To compare the condition of auditory function during the first year of life according to the registration of distortion product otoacoustic emission (DPOAE) and short-latency evoked potentials (SLEP) in premature infants who received ototoxic antibiotics to those ones, who did not.
Material And Methods:
Auditory function was examined in 145 premature infants. Auditory assessment was carried out by registration of DPOAEs, SLEPs and tympanometry. Statistical processing was performed using the program Statgraphics Centurion XV.
Results:
In this study, according to DPOAE, the average response values of the cochlea in premature infants who had a history of ototoxic therapy, undergo final changes after children reach the age of 6 months. The study of latent periods and threshold values of the V peak of SLEP showed a delay in the maturation process of the perceiving and conducting auditory structures during the first year of life in children who received ototoxic antibiotics in the first month of life.
Conclusion:
We evaluated the timing of the completion of response changes in children of the control group using the DPOAE and SLEP registration data. In children of the study group, we evaluated the effect of the administered ototoxic antibiotics. Timing of audiological control of the hearing organ condition are demonstrated for premature children after ototoxicosis, required methods of its examination are established.
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