Related Experiment Video

Updated: Oct 13, 2025

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

305

Evaluation of a multimarker panel in chronic heart failure: a 10-year follow-up

Susanne Bauer1, Christina Strack1, Ekrem Ücer1

  • 1University Hospital Regensburg, Department for Cardiology, Franz-Josef-Strauss Allee 11, Regensburg, 93053, Germany.

Biomarkers in Medicine
|November 16, 2021
PubMed

Insights

This study identified three key biomarkers for predicting heart failure mortality over 10 years. Elevated levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT), and insulin-like growth factor-binding protein 7 (IGF-BP7) indicate a high mortality risk.

Area of Science:

  • Biomarker discovery
  • Cardiovascular research
  • Prognostic modeling

Background:

  • Heart failure (HF) poses a significant global health burden.
  • Accurate prognostic markers are crucial for managing HF patients.
  • Existing biomarkers have limitations in predicting long-term outcomes.

Purpose of the Study:

  • To evaluate the 10-year prognostic value of 11 diverse biomarkers in heart failure patients.
  • To identify a combination of biomarkers for improved mortality risk stratification.
  • To validate a multimarker model for long-term prognosis in heart failure.

Main Methods:

  • Analysis of blood samples from 144 heart failure patients.
  • 10-year follow-up for all-cause mortality data acquisition.
  • Kaplan-Meier analysis and multimarker model development using NT-proBNP, hs-TnT, and IGF-BP7.

Main Results:

  • Most biomarkers, excluding TIMP-1 and GDF-15, were significant predictors of all-cause mortality.
  • A multimarker model combining NT-proBNP, hs-TnT, and IGF-BP7 demonstrated strong prognostic capability.
  • Patients with elevated levels of all three markers exhibited a significantly worse long-term prognosis.

Conclusions:

  • A combination of NT-proBNP, hs-TnT, and IGF-BP7 effectively identifies high-risk heart failure patients.
  • This three-biomarker panel offers a valuable tool for 10-year mortality risk assessment in HF.
  • The findings support the use of this multimarker approach for personalized HF management.

Keywords:
IGF-BP7NT-proBNPheart failurehs-TnTmultimarker panelprognostication

More Related Videos

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.5K
Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery08:17

Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery

Published on: February 20, 2017

14.6K

Related Concept Videos

Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
73
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
100
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
86
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
43
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
48
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
126