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Updated: Oct 13, 2025
11:25
A G-quadruplex DNA-affinity Approach for Purification of Enzymatically Active G4 Resolvase1
Published on: March 18, 2017
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G4-PROTAC: targeted degradation of a G-quadruplex binding protein
Kiran M Patil1, Danielle Chin1, Hui Ling Seah1
1School of Physical and Mathematical Sciences, Nanyang Technological University, 637371, Singapore. phantuan@ntu.edu.sg.
Chemical Communications (Cambridge, England)
|November 16, 2021
Abstract:
G-quadruplex (G4) binding proteins regulate important biological processes, but their interaction networks are poorly understood. We report the first use of G4 as a warhead of a proteolysis-targeting chimera (G4-PROTAC) for targeted degradation of a G4-binding protein (RHAU/DHX36). G4-PROTAC provides a new way to explore G4-protein networks and to develop potential therapeutics.
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