Related Experiment Video
Updated: Oct 13, 2025
An Orthotopic Murine Model of Human Prostate Cancer Metastasis
Published on: September 18, 2013
Oxaliplatin inhibits angiogenin proliferative and cell migration effects in prostate cancer cells
Tiziano Marzo1, Giarita Ferraro2, Lorena Maria Cucci3
1Department of Pharmacy, University of Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy.
Abstract:
Angiogenin (Ang) is a potent angiogenic protein that is overexpressed in many types of cancer at concentration values correlated to the tumor aggressiveness. Here, by means of an integrated multi-technique approach based on crystallographic, spectrometric and spectroscopic analyses, we demonstrate that the anti-cancer drug oxaliplatin efficiently binds angiogenin. Microscopy cellular studies, carried out on the prostate cancer cell (PC-3) line , show that oxaliplatin inhibits the angiogenin prompting effect on cell proliferation and migration, which are typical features of angiogenesis process. Overall, our findings point to angiogenin as a possible target of oxaliplatin, thus suggesting a potential novel mechanism for the antineoplastic activity of this platinum drug and opening the avenue to novel approaches in the combined anti-cancer anti-angiogenic therapy.
Insights
Oxaliplatin effectively binds to angiogenin (Ang), a protein linked to cancer growth. This interaction inhibits cancer cell proliferation and migration, suggesting a new therapeutic strategy for combined anti-cancer and anti-angiogenic therapy.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- Angiogenin (Ang) is a key protein promoting angiogenesis, a process vital for tumor growth and metastasis.
- Ang is frequently overexpressed in various cancers, with levels correlating to tumor aggressiveness.
Purpose of the Study:
- To investigate the interaction between the anti-cancer drug oxaliplatin and angiogenin.
- To elucidate the functional consequences of this interaction on cancer cell behavior.
Main Methods:
- Integrated multi-technique approach including crystallographic, spectrometric, and spectroscopic analyses.
- Cellular microscopy studies using the prostate cancer cell (PC-3) line.
Main Results:
- Oxaliplatin demonstrated efficient binding to angiogenin.
- Oxaliplatin treatment inhibited Ang-induced cancer cell proliferation and migration.
- These findings suggest Ang is a potential molecular target of oxaliplatin.
Conclusions:
- Angiogenin is identified as a potential target of oxaliplatin.
- This interaction offers a novel mechanism for oxaliplatin's antineoplastic activity.
- The study opens avenues for combined anti-cancer and anti-angiogenic therapies.
More Related Videos
09:40Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer
Published on: August 2, 2024
07:59Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1
Published on: December 5, 2020
