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Diagnostic biomarkers of dilated cardiomyopathy

Aysan Moeinafshar1, Niloufar Yazdanpanah2, Nima Rezaei3

  • 1School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.

Immunobiology
|November 16, 2021
PubMed

Insights

Cardiac biomarkers are crucial for diagnosing and predicting dilated cardiomyopathy (DCM). This review categorizes and discusses these biomarkers, highlighting their diagnostic and prognostic potential for early disease detection.

Area of Science:

  • Cardiology
  • Biomarker Research

Background:

  • Dilated cardiomyopathy (DCM) involves cardiac chamber dilation and impaired contraction.
  • Cardiac biomarkers are vital for DCM diagnosis and prognosis.
  • Biomarkers are classified into cardiomyocyte, microenvironmental, and macroenvironmental types.

Purpose of the Study:

  • To review the characteristics, epidemiology, etiology, and clinical manifestations of DCM.
  • To discuss key biomarkers across all three categories.
  • To evaluate the diagnostic and prognostic value of these biomarkers.

Main Methods:

  • Literature review of DCM and cardiac biomarkers.
  • Categorization of biomarkers based on their site of origin.
  • Analysis of diagnostic and prognostic utility.

Main Results:

  • DCM is associated with infections and autoimmunity.
  • Cardiomyocyte, microenvironmental, and macroenvironmental biomarkers show potential.
  • Biomarkers aid in DCM diagnosis and prognosis.

Conclusions:

  • Efficient diagnostic tools for early DCM detection are valuable.
  • The discussed biomarker classes are promising for DCM detection.
  • Further research is needed to validate biomarker efficacy.
Abstract

Keywords:
BiomarkerDCMDiagnosisDilated cardiomyopathyPrognosis

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