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Immunotherapy for gastric cancer: a 2021 update

Christo Kole1, Nikolaos Charalampakis2, Sergios Tsakatikas2

  • 1First Department of Surgery, National & Kapodistrian University of Athens, Laikon General Hospital, Athens, 115 27, Greece.

Immunotherapy
|November 17, 2021
PubMed

Insights

Immunotherapy offers promising treatment options for advanced gastric cancer, improving patient outcomes. This review examines current clinical trials and immunotherapy efficacy based on tumor genetics.

Area of Science:

  • Oncology
  • Immunology
  • Gastroenterology

Background:

  • Gastric cancer is a leading cause of cancer death globally.
  • Many patients are diagnosed with advanced or metastatic disease, precluding surgery.
  • Immunotherapy has emerged as a significant therapeutic strategy for various cancers.

Purpose of the Study:

  • To summarize ongoing clinical trials for gastric cancer immunotherapy.
  • To critically evaluate the efficacy of diverse immunotherapy approaches.
  • To analyze immunotherapy effectiveness in relation to tumor genetic profiling.

Main Methods:

  • Systematic review of current clinical trials.
  • Analysis of immunotherapy efficacy data.
  • Correlation of treatment response with tumor genetic markers.

Main Results:

  • Ongoing trials are exploring various immunotherapy agents and combinations.
  • Immunotherapy demonstrates variable efficacy across different patient subgroups.
  • Tumor genetic profiling is crucial for predicting treatment response.

Conclusions:

  • Immunotherapy represents a vital treatment avenue for advanced gastric cancer.
  • Personalized treatment strategies based on genetic profiling are essential for optimizing outcomes.
  • Further research is needed to fully elucidate immunotherapy's role in gastric cancer management.
Keywords:
adoptive cell therapycancer vaccinescheckpoint inhibitorsgastric cancerimmunotherapymicrosatellite instabilitytumor mutational burden

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