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Curcumin inhibits ovarian cancer progression by regulating circ-PLEKHM3/miR-320a/SMG1 axis

Sifan Sun1, Hailiang Fang2

  • 1Department of Rehabilitation, The Second Hospital of Dalian Medical University, Dalian City, Liaoning Province, China.

Journal of Ovarian Research
|November 17, 2021
PubMed
Abstract

Insights

Curcumin inhibits ovarian cancer by regulating the circ-PLEKHM3/miR-320a/SMG1 pathway. This study clarifies curcumin

Area of Science:

  • Molecular Oncology
  • Biochemistry

Background:

  • Curcumin shows potential in ovarian cancer therapy.
  • The precise molecular mechanisms, particularly involving the circRNA/miRNA/mRNA network, remain unclear.

Purpose of the Study:

  • To investigate the role of curcumin in ovarian cancer.
  • To elucidate the involvement of the circ-PLEKHM3/miR-320a/SMG1 axis in curcumin's anti-cancer effects.

Main Methods:

  • Quantitative real-time PCR (qRT-PCR) for gene expression analysis.
  • Cell viability, apoptosis, and colony formation assays.
  • Western blot, dual-luciferase reporter assays, and RIP assays.

Main Results:

  • Curcumin suppressed ovarian cancer cell proliferation and induced apoptosis.
  • Circ-PLEKHM3 was downregulated in ovarian cancer and its expression was increased by curcumin.
  • Circ-PLEKHM3 acts as a sponge for miR-320a, which targets SMG1, forming a regulatory axis.

Conclusions:

  • Curcumin exerts anti-cancer effects in ovarian cancer by modulating the circ-PLEKHM3/miR-320a/SMG1 axis.
  • This pathway represents a potential therapeutic target for ovarian cancer treatment.
Keywords:
Circ-PLEKHM3CurcuminOvarian cancerSMG1miR-320a

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