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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
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Cannabis and the skin.

Kimberly Shao1, Campbell Stewart1, Jane M Grant-Kels1

  • 1Department of Dermatology, University of Connecticut School of Medicine, Farmington, Connecticut, USA.

Clinics in Dermatology
|November 17, 2021
PubMed
Summary

Cannabis shows potential for treating skin conditions by regulating pain, inflammation, and itching. Further research is exploring its use in various dermatologic diseases and potential side effects.

Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Growing public and healthcare interest in the medical benefits of Cannabis.
  • In vitro and in vivo studies suggest cannabinoids may regulate pain, pruritus, and inflammation.
  • The existing body of research on cannabinoids in dermatology is nascent but expanding.

Purpose of the Study:

  • To review current research on cannabinoids in dermatology.
  • To discuss potential cutaneous adverse effects of cannabinoid use.
  • To explore future directions for cannabinoid research in various skin conditions.

Main Methods:

  • Literature review of in vitro and in vivo studies.
  • Analysis of research on cannabinoids and dermatologic conditions.
  • Examination of reported adverse effects and future research avenues.

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Main Results:

  • Cannabinoids show promise for managing symptoms like pain, pruritus, and inflammation in dermatologic conditions.
  • Research is ongoing for applications in skin cancer, acne, psoriasis, dermatitis, and autoimmune blistering diseases.
  • Potential adverse effects on the skin are also under investigation.

Conclusions:

  • Cannabinoids represent a potentially attractive therapeutic agent for numerous dermatologic conditions.
  • Further research is warranted to fully understand the efficacy, safety, and optimal use of cannabinoids in dermatology.
  • The review covers a broad spectrum of conditions, including inflammatory, autoimmune, oncologic, and wound healing applications.