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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Related Experiment Video

Updated: Oct 13, 2025

Hyperpolarized Xenon for NMR and MRI Applications

Hyperpolarized Xenon for NMR and MRI Applications

Published on: September 6, 2012

Hyperpolarized MRI - An Update and Future Perspectives.

S H Jørgensen¹, N Bøgh², Ess Hansen²

¹The MR Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; The Department of Cardiology, Aarhus University Hospital, Aarhus N, Denmark; The Department of Cardiology, North Denmark Regional Hospital, Hjørring, Denmark.

Seminars in Nuclear Medicine

|November 17, 2021

Summary

This summary is machine-generated.

Hyperpolarized ¹³C magnetic resonance spectroscopic (MRS) imaging offers a non-invasive method to visualize cellular metabolism. This advanced technique, particularly using [1-¹³C]pyruvate, provides unprecedented metabolic insights for clinical applications.

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Last Updated: Oct 13, 2025

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Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

Published on: December 30, 2016

Area of Science:

Nuclear Medicine
Biomedical Imaging
Metabolic Imaging

Background:

Hyperpolarized ¹³C magnetic resonance spectroscopic (MRS) imaging is an emerging metabolic imaging technique.
Dissolution dynamic nuclear polarization enhances the MR signal of ¹³C-enriched molecules by over 10⁴.
This enables detection of downstream metabolites in intracellular metabolic pathways.

Purpose of the Study:

To provide an update on hyperpolarized ¹³C MRS imaging.
To assess the future clinical potential of this metabolic imaging technology.

Main Methods:

Review of studies utilizing carbon-based probes for hyperpolarized ¹³C MRS imaging.
Focus on [1-¹³C]pyruvate as the primary probe in clinical studies.
Detection of intracellular [1-¹³C]lactate and ¹³C-bicarbonate production.

Main Results:

Hyperpolarized [1-¹³C]pyruvate MRS imaging non-invasively detects metabolic products in real-time.
It images the Warburg effect in tumors and hallmarks of ischemia or viability in the myocardium.
Clinical studies confirm the feasibility and value of hyperpolarized ¹³C MRS imaging for inaccessible metabolic information.

Conclusions:

Hyperpolarized ¹³C MRS imaging is a viable clinical tool providing unique metabolic insights.
While still developing, it holds significant promise for future integrated metabolic imaging.
Nuclear medicine physicians should familiarize themselves with its capabilities and limitations.