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Anesthetics mediated the immunomodulatory effects via regulation of TLR signaling

Yan Liu1, Li Liu2, Wanying Xing3

  • 1Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun, 130033, China.

International Immunopharmacology
|November 17, 2021
PubMed

Anesthetics have been widely used in surgery and found to suppress inflammatory injury and affect the outcomes of the surgery and diseases. In contrast, anesthetics are also found to induce neuronal injury and inflammation. However, the immune-modulation mechanism of anesthetics is still not clear. Recent studies have shown that the immune-modulation of anesthetics is associated with the regulation of toll-like receptor (TLR)-mediated signaling. Moreover, the regulation of anesthetics in TLR signaling is related to modulations of non-coding RNAs (nc RNAs). Consistently, nc RNAs are mainly divided into micro RNAs (miRs) and long non-coding RNAs (lnc RNAs), which have been found to exert regulatory effects on the immune system. In this review, we summarize the immunomodulatory functions of the widely used anesthetic agents, which are associated with regulation of TLR signaling. In addition, we also focus on the roles of nc RNAs induced by anesthetics in regulations of TLR signaling.

Keywords:
AnestheticsImmunomodulatory effectsLnc RNATLRsmicro RNA

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