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Related Concept Videos

Drug Product Stability01:16

Drug Product Stability

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The long-term stability of drug products is critical to ensuring their quality, safety, and effectiveness over time. Stability directly influences a product's ability to maintain its intended characteristics, ensuring it performs as expected during its intended shelf life. Key attributes such as drug potency, impurities, dissolution, and other physicochemical measures of performance are tested to assess stability. These parameters indicate how well the product retains its quality over time and...
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Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

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Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
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Stability of Substituted Cyclohexanes02:30

Stability of Substituted Cyclohexanes

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This lesson discusses the stability of substituted cyclohexanes with a focus on energies of various conformers and the effect of 1,3-diaxial interactions.
The two chair conformations of cyclohexanes undergo rapid interconversion at room temperature. Both forms have identical energies and stabilities, each comprising equal amounts of the equilibrium mixture. Replacing a hydrogen atom with a functional group makes the two conformations energetically non-equivalent.
For example, in...
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Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

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Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Related Experiment Video

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Author Spotlight: Eco-friendly Photoluminescent Textile Authentication with Curcumin
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Shedding light on curcumin stability.

Giovanni Appendino1, Pietro Allegrini2, Eric de Combarieu2

  • 1University of Eastern Piedmont, Department of Pharmaceutical Sciences, Largo Donegani 2, 28100 Novara, Italy.

Fitoterapia
|November 17, 2021
PubMed
Summary
This summary is machine-generated.

Curcumin stability depends heavily on light exposure and pH. Intense light and solar radiation cause degradation, while minor curcuminoids offer some protection under low light conditions.

Keywords:
BicyclopentandioneCurcuminFerulic acidPhotodegradationTurmeric

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Area of Science:

  • Photochemistry
  • Natural Product Chemistry
  • Analytical Chemistry

Background:

  • Curcumin (purcumin) exhibits light-dependent stability in solution.
  • Previous studies have noted curcumin's instability, but rationales remain unclear.
  • Commercial curcumin contains minor curcuminoids that may influence stability.

Purpose of the Study:

  • To investigate the light-dependent stability of molecular curcumin (purcumin).
  • To elucidate the degradation pathways of curcumin under various light conditions.
  • To assess the role of minor curcuminoids in enhancing curcumin stability.

Main Methods:

  • Exposure of curcumin solutions to laboratory artificial light and simulated solar light.
  • Analysis of degradation products using hydrolytic and oxidative fragmentation.
  • Evaluation of stability at different pH levels.
  • Comparison of stability with and without minor curcuminoids.

Main Results:

  • Curcumin stability is pH-dependent under laboratory light, with neutral pH showing relative stability.
  • Intense light and solar light induce degradation via hydrolysis and oxidation of the heptadiendione moiety.
  • Minor curcuminoids improve curcumin stability, but only under low irradiation conditions.
  • Degradation mechanisms and the influence of light intensity were clarified.

Conclusions:

  • Curcumin's instability is confirmed and further elucidated by light-dependent degradation pathways.
  • The biological relevance of non-enzymatic curcumin degradation for reported bioactivity needs re-evaluation.
  • Further characterization of curcuminoid degradation under visible light is necessary for accurate therapeutic application.