Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Randomized Experiments01:13

Randomized Experiments

8.2K
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
8.2K
Crossover Experiments01:16

Crossover Experiments

4.0K
Crossover experiments, also called the repeated-measurements design, is a study design in which all experimental units are exposed to all treatments in different periods. Crossover experiments are generally used in psychology, the pharmaceutical industry, agriculture, and medicine.
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.
4.0K
Clinical Trials01:16

Clinical Trials

9.7K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
9.7K
Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs01:15

Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs

22
Body:Bioequivalence experimental study designs play a pivotal role in testing the effectiveness of various treatments. Key among these are the repeated measures, cross-over, carry-over, and Latin square designs. In the repeated measures design, each subject receives all treatments, allowing for temporal comparisons. This type of design is useful in reducing variability but requires careful planning to avoid bias.The cross-over design, an economical method, involves sequential administration of...
22
Clinical Trials: Overview01:11

Clinical Trials: Overview

3.7K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
3.7K
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs01:20

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

9
Body:Bioequivalence experimental study designs are crucial methodologies used in evaluating and comparing the bioavailability of different drug products. These designs are categorized into various types: completely randomized, randomized block, repeated measures, cross and carry-over, and Latin square designs.Completely randomized designs involve randomly allocating treatments to all subjects participating in the experiment. This allocation is achieved by assigning unique random numbers to...
9

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Noninferiority of Online Versus In-Person Training for Health Professionals Delivering the COPE Dementia Care Program in PACE Settings.

The American journal of geriatric psychiatry. Open science, education, and practice·2026
Same author

Pragmatic Trials: The Importance of Foundational Research, Fidelity, Implementation, and Context.

Annals of internal medicine·2026
Same author

Using United States medicare program claims to identify reliable measures of low value services influenced by primary care physician decisions.

BMC health services research·2026
Same author

What do health insurance deductibles do to health care spending growth?

International journal of health economics and management·2026
Same author

Methods for measuring implementation fidelity to the transitional care model.

Trials·2026
Same author

Virtual health coaching to improve self-care among informal caregivers of hospitalized older adults during a transition in care: Randomized controlled trial study protocol.

Contemporary clinical trials·2026

Related Experiment Video

Updated: Oct 13, 2025

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
08:53

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Published on: June 6, 2025

789

MIRROR-TCM: Multisite Replication of a Randomized Controlled Trial - Transitional Care Model.

Mary D Naylor1, Karen B Hirschman1, Kathleen McCauley1

  • 1NewCourtland Center for Transitions and Health, University of Pennsylvania School of Nursing, 418 Curie Blvd., Philadelphia, PA 19103, United States of America.

Contemporary Clinical Trials
|November 17, 2021
PubMed
Summary

The Transitional Care Model (TCM) reduces hospital readmissions for older adults with chronic conditions. This study shows TCM improves patient outcomes and lowers healthcare costs by supporting care transitions from hospital to home.

Keywords:
Intervention protocolOlder adultsOutcomesRehospitalizationTransitional care

More Related Videos

A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program
04:24

A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program

Published on: April 19, 2019

11.9K
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

10.8K

Related Experiment Videos

Last Updated: Oct 13, 2025

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
08:53

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Published on: June 6, 2025

789
A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program
04:24

A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program

Published on: April 19, 2019

11.9K
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

10.8K

Area of Science:

  • Gerontology
  • Health Services Research
  • Nursing

Background:

  • Older adults face high rehospitalization rates within 30 days of discharge due to complex chronic conditions.
  • Current management often fails to adequately address the multifaceted needs of this vulnerable population.
  • The Transitional Care Model (TCM) is a proven, nurse-led intervention designed to support older adults during care transitions.

Purpose of the Study:

  • To evaluate the effectiveness of replicating the Transitional Care Model (TCM) across multiple U.S. healthcare systems.
  • To compare health and economic outcomes between older adults receiving TCM and those receiving usual discharge planning.
  • To assess the impact of TCM on rehospitalization rates, resource utilization, patient experience, and quality of life.

Main Methods:

  • A prospective, intent-to-treat, randomized controlled trial (RCT) involving 1600 at-risk older adults hospitalized with heart failure, COPD, or pneumonia.
  • Participants were randomized to either the TCM protocol or usual discharge planning (control group).
  • Primary outcome: rehospitalizations at 12 months. Secondary outcomes: resource use, patient experience, health, and quality of life at 90 days.

Main Results:

  • The study hypothesizes that the TCM group will experience decreased acute care resource use and costs at 12 months.
  • It is also hypothesized that the TCM group will report better care experience and health/quality of life outcomes through 90 days post-discharge.
  • The impact of COVID-19 on study implementation is also discussed.

Conclusions:

  • The Transitional Care Model (TCM) is expected to reduce acute care utilization and costs for older adults with chronic conditions.
  • TCM is anticipated to enhance patient-reported outcomes, including care experience and quality of life.
  • This study will provide further evidence on the scalability and effectiveness of TCM in diverse healthcare settings.