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Correlation between hyperglycemia and glycated albumin with retinopathy of prematurity

Ana C Almeida1,2,3,4,5, Gabriela A Silva6, Gabriele Santini7

  • 1Department of Ophthalmology, Hospital Beatriz Angelo, Loures, Av. Carlos Teixeira 3, 2674-514, Loures, Portugal. acralmeida@yahoo.com.

Scientific Reports
|November 17, 2021
PubMed

Insights

Hyperglycemia, or high blood sugar, is a significant risk factor for retinopathy of prematurity (ROP). Glycated albumin (GlyA) levels were not found to be a significant predictor of ROP in premature infants.

Area of Science:

  • Neonatal Medicine
  • Ophthalmology
  • Endocrinology

Background:

  • Retinopathy of prematurity (ROP) is a leading cause of visual impairment in premature infants.
  • Hyperglycemia and glycated albumin (GlyA) are potential risk factors for ROP, but their association requires further investigation.

Purpose of the Study:

  • To determine the association between hyperglycemia, glycated albumin (GlyA), and retinopathy of prematurity (ROP) in a cohort of premature infants.
  • To identify significant risk factors for ROP development.

Main Methods:

  • Prospective study of 152 infants requiring ROP screening between March 2017 and July 2019.
  • Collected demographic, clinical, and laboratory data, including glucose measurements and serum GlyA levels at multiple time points.
  • Employed univariate and multivariate logistic regression analyses to assess risk factors for ROP.

Main Results:

  • Thirty-three infants (21.7%) developed ROP.
  • Hyperglycemia was present in 72.7% of infants with ROP compared to 0.05% without ROP.
  • Multivariate analysis identified hyperglycemia as a significant independent risk factor for ROP (Exp(B) 28.062, p < 0.001), while GlyA was not significant.

Conclusions:

  • Hyperglycemia is a critical and independent risk factor for retinopathy of prematurity in premature infants.
  • Glycated albumin (GlyA) levels do not appear to be a significant predictor of ROP in this cohort.
  • Findings emphasize the importance of glycemic control in preventing ROP.

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