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[Significance and selected examples for using determinations of isoenzyme of alkaline phosphatase in pediatrics]
E Schönau1, K H Herzog, H J Böhles
1Kinderklinik und Poliklinik, Friedrich-Alexander-Universität Erlangen-Nürnberg.
Insights
Interpreting total alkaline phosphatase in children is challenging due to varying normal ranges. Isoenzyme analysis in pediatric patients reveals crucial clinical insights for diagnosing various conditions.
Area of Science:
- Biochemistry
- Pediatric Medicine
- Clinical Chemistry
Context:
- Total alkaline phosphatase (ALP) interpretation in pediatric patients is complex.
- Normal ALP values vary significantly across different pediatric age groups.
- Pediatric liver diseases and other conditions can alter ALP levels.
Purpose:
- To investigate the clinical relevance of alkaline phosphatase isoenzyme determination in pediatric patients.
- To differentiate causes of elevated ALP in children.
- To assess the utility of ALP isoenzymes in specific pediatric conditions.
Summary:
- This study analyzed alkaline phosphatase isoenzymes in 32 pediatric patients.
- Cases included rickets, hepatitis, cirrhosis, congenital bile duct atresia, and those undergoing cytostatic or anticonvulsant therapy.
- Isoenzyme separation provided clinically relevant diagnostic information.
Impact:
- Highlights the importance of ALP isoenzyme analysis for accurate pediatric diagnosis.
- Offers a more refined diagnostic approach compared to total ALP alone.
- Aids in understanding the etiology of elevated ALP in diverse pediatric conditions.
Abstract:
The interpretation of total alkaline phosphatase in paediatric patients is complicated by the wide range of normal values in the various age groups. Selected separations of isoenzymes in cases of rickets, hepatitis, cirrhosis, congenital atresia of the bile duct, during cytostatic or anticonvulsant therapy in 32 paediatric patients demonstrate the clinical relevance of isoenzyme determination.