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Interleukin-35: Structure, Function and Its Impact on Immune-Related Diseases
Cheng Ye1, Hiroshi Yano1,2, Creg J Workman1
1Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Summary
Interleukin-35 (IL-35) is a key cytokine that suppresses immune responses and regulates T cells. This review explores IL-35
Area of Science:
- Immunology
- Molecular Biology
- Cytokine Signaling
Background:
- Immune homeostasis relies on a balance between inflammatory and anti-inflammatory responses.
- Immunoregulatory cells and immunosuppressive cytokines are crucial for maintaining this balance.
- Interleukin-35 (IL-35) is an inhibitory cytokine within the IL-12 family with potent immune-suppressive functions.
Purpose of the Study:
- To review the biological functions of Interleukin-35 (IL-35).
- To summarize the role of IL-35 in various immune-related disorders.
- To discuss the therapeutic potential and challenges of utilizing IL-35 in clinical settings.
Main Methods:
- Literature review of studies on IL-35 biology and function.
- Analysis of IL-35's involvement in autoimmune diseases, infectious diseases, and cancer.
- Discussion of IL-35 as a potential clinical biomarker and immunotherapy target.
Main Results:
- IL-35 potently suppresses T cell proliferation.
- IL-35 induces the development of IL-35-producing induced regulatory T cells (iTr35).
- IL-35 plays a significant role in controlling immune-related disorders.
Conclusions:
- IL-35 is a critical regulator of immune responses.
- IL-35 has demonstrated importance in managing autoimmune diseases, infections, and cancer.
- Harnessing IL-35 for clinical applications presents both opportunities and challenges.
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