Related Experiment Video
Updated: Oct 13, 2025

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
Meat consumption and gastric cancer risk: the Japan Public Health Center-based Prospective Study
Calistus Wilunda1, Taiki Yamaji1, Motoki Iwasaki1
1Epidemiology and Prevention Group, Institute for Cancer Control, National Cancer Center, Tokyo, Japan.
Background:
The association of meat consumption with gastric cancer is inconclusive.
Objectives:
We examined the association of meat consumption with gastric cancer risk among Japanese men and women.
Methods:
This cohort study included 42,328 male and 48,176 female participants of the Japan Public Health Center-based Prospective Study, who were aged 45 to 74 y at recruitment. Dietary intake data were collected from 1 January 1995 to 31 December 1999 using a validated food-frequency questionnaire. HRs and 95% CIs for gastric cancer were estimated using Cox proportional hazards regression models.
Results:
During a mean follow-up of 15 y, 1868 male and 833 female incident gastric cancer cases were identified. Intake of total and subtypes of meat was not associated with total gastric cancer. However, higher chicken consumption was associated with reduced distal gastric cancer risk in women (HR for quintile 5 vs. quintile 1: 0.75; 95% CI: 0.56, 0.99; P-trend = 0.027), with a similar but nonsignificant risk reduction among women with Helicobacter pylori (HR: 0.59; 95% CI: 0.29, 1.20; P-trend = 0.06) in subgroup analysis.
Conclusions:
Meat consumption was not associated with total gastric cancer risk.
Related Concept Videos
Cancer Prevention
Some...
Assessment of the Gastrointestinal System II: Health Perception Pattern
Health Perception Patterns
Health perception patterns offer valuable insights into a patient's lifestyle habits and how they may impact their GI health. These patterns include:
Gastric Emptying
Gastric Phase of Digestion
When food enters the stomach, it stretches the stomach walls and activates stretch receptors. This triggers local reflexes of the enteric nervous system, mediated through the myenteric plexus. These...
Stomach pH Regulation
The acid-secreting gastric mucosal epithelial cells (parietal cells) lining the stomach lumen maintain the low pH in the lumen. Numerous ion transporters and channels on these parietal...
Regulation of Food Intake

