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Related Concept Videos

Clinical Trials01:16

Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Clinical Trials: Overview01:11

Clinical Trials: Overview

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Continuing Care01:25

Continuing Care

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Continuing care describes the variety of health, personal, and social services provided over a prolonged period. The need for continuing care is increasing because people are living longer. Many people do not have families or others to care for them. Continuing care is mainly for patients who are disabled, functionally dependent, or suffering from a terminal disease. It is available within institutional settings or in homes. Examples include nursing centers or facilities, assisted living,...
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Patient-centered Care01:13

Patient-centered Care

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Patient-centered care involves delivering care beyond inpatient hospitalization. Reflective practice can enhance a patient-centered approach. Reflective practice is a process of reasoning that considers all aspects of the present situation, including practicalities, learning from personal practice, and consideration of patient needs. Patients appreciate care decisions made while considering their input. Involving the patient in their care provides the patient with a sense of contribution rather...
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Treatment Resistant Cancers02:56

Treatment Resistant Cancers

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Preclinical Development: Overview01:28

Preclinical Development: Overview

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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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Palliative Care Clinical Trials: Building Capability and Capacity.

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Establishing palliative care clinical trials is feasible and acceptable, increasing evidence-based care. This program successfully expanded trial activity and patient participation across multiple sites.

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Area of Science:

  • Palliative care research
  • Clinical trial methodology
  • Health services research

Background:

  • Clinical trials are crucial for advancing palliative care evidence.
  • The Victorian Comprehensive Cancer Centre (VCCC) aimed to boost palliative care clinical trial expertise.
  • Palliative care services within VCCC had potential for trial development but lacked active centers.

Purpose of the Study:

  • To establish a multi-site program to build capability in palliative care clinical trials.
  • To assess the strategies, activities, and outcomes of this service development program.

Main Methods:

  • Developed strategies targeting increased clinical sites, skilled clinicians, trial availability, patient participation, research opportunities, and program sustainability.
  • Implemented a program over two years across five palliative care services.

Main Results:

  • Conducted Phase 1, 2, and 3 trials, alongside Phase 4 pharmacovigilance studies.
  • Recruited 150 patients to clinical trials and recorded 258 pharmacovigilance cases.
  • Developed five investigator-initiated trials, securing competitive or commercial funding.
  • Clinicians reported increased focus on evidence-based care and broader research activity.

Conclusions:

  • Clinical trials in palliative care are feasible, acceptable, and enhance evidence-based care.
  • The program's framework and outcomes can guide implementation in other sites and disciplines.
  • Long-term sustainability presents a challenge, exacerbated by the COVID-19 pandemic.