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Management of hepatitis B and C in special population

Anand V Kulkarni1, Nageshwar Reddy Duvvuru2

  • 1Department of Hepatology, Asian Institute of Gastroenterology, Hyderabad 500032, Telangana, India. anandvk90@gmail.com.

World Journal of Gastroenterology
|November 18, 2021
PubMed

Insights

New oral antiviral therapies offer effective treatment for chronic hepatitis B (CHB) and chronic hepatitis C (CHC). This review examines their use in special populations, including those with kidney disease and pregnant women.

Area of Science:

  • Hepatology
  • Virology
  • Pharmacology

Background:

  • Chronic viral hepatitis B and C are major global causes of cirrhosis.
  • Hepatitis B is prevalent in the Asia-Pacific, while Hepatitis C is more common in the West.
  • Recent advancements include oral direct-acting antivirals (DAAs) for CHC and nucleos(t)ide analogs (NUCs) for CHB.

Purpose of the Study:

  • To review the management of chronic hepatitis B and C in special patient populations.
  • To discuss the evolving safety and efficacy data of oral antiviral therapies in these groups.

Main Methods:

  • Literature review of current clinical guidelines and research.
  • Analysis of treatment outcomes and safety profiles in specific populations.

Main Results:

  • Oral DAAs and NUCs demonstrate high efficacy, good tolerability, and low resistance rates.
  • Robust data is lacking for certain special populations, requiring ongoing research.

Conclusions:

  • Oral antiviral therapies have revolutionized CHB and CHC management.
  • Further investigation is needed to optimize treatment strategies for special populations, including those with chronic kidney disease, pregnant women, healthcare workers, and immunocompromised individuals.

Keywords:
Chronic kidney diseaseHealth care professionalsHepatitis BHepatitis CPregnancyTenofovir

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