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Plasmodium falciparum Multidrug Resistance Proteins (pfMRPs)

José Pedro Gil1,2,3, Cláudia Fançony4

  • 1Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

Frontiers in Pharmacology
|November 18, 2021
PubMed

Insights

Antimalarial drug resistance in Plasmodium falciparum is a major hurdle. Multidrug Resistance Proteins (MRPs) in the parasite are key to evading drug action and may drive resistance, necessitating a review of current knowledge.

Area of Science:

  • Parasitology
  • Molecular Biology
  • Pharmacology

Background:

  • Antimalarial drug resistance in *Plasmodium falciparum* is a significant global health challenge.
  • Drug transporters, particularly Multidrug Resistance Proteins (MRPs), are implicated in parasite evasion of antimalarial drugs.
  • MRPs handle diverse substrates, including glutathione, and are linked to drug resistance across various organisms.

Purpose of the Study:

  • To consolidate and review the scattered information on *Plasmodium falciparum* Multidrug Resistance Proteins (MRPs).
  • To highlight the role of *P. falciparum* MRPs in altered drug responses and potential multi-drug resistance.
  • To provide a specialized review addressing the current state of knowledge on these crucial parasite proteins.

Main Methods:

  • Literature review of existing studies on *Plasmodium falciparum* MRPs.
  • Analysis of the known functions and substrates of MRPs in other organisms.
  • Synthesis of information regarding the association of *P. falciparum* MRPs with in vivo and in vitro drug responses.

Main Results:

  • *Plasmodium falciparum* MRPs are associated with altered responses to antimalarial drugs.
  • These transporters may contribute to the development of multi-drug resistance phenotypes.
  • Existing information on *P. falciparum* MRPs is fragmented across various publications.

Conclusions:

  • Understanding *P. falciparum* MRPs is critical for combating antimalarial drug resistance.
  • These proteins represent potential targets for novel therapeutic strategies.
  • A comprehensive review is needed to guide future research and drug development efforts.
Keywords:
ABC proteinMRPPlasmodium falciparummalariamultidrug resistance

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