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Recent Progresses in NIR-I/II Fluorescence Imaging for Surgical Navigation.

Songjiao Li¹, Dan Cheng^2,3, Longwei He¹

¹Cancer Research Institute, Department of Pharmacy and Pharmacology, The First Affiliated Hospital, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical School, University of South China, Hengyang, China.

Frontiers in Bioengineering and Biotechnology

|November 18, 2021

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This summary is machine-generated.

Near-infrared (NIR) fluorescence imaging enhances cancer surgery by improving tumor margin visualization. This review covers NIR-I and NIR-II fluorescence molecular imaging principles and applications in image-guided cancer surgeries.

Area of Science:

Biomedical Engineering
Oncology
Medical Imaging

Background:

Cancer remains a leading cause of mortality globally, necessitating advanced treatment strategies.
Surgical resection is a primary treatment for solid tumors, but complete removal of cancerous tissue is challenging.
Near-infrared (NIR) fluorescence imaging offers advantages like deep tissue penetration and low light scattering for enhanced visualization.

Purpose of the Study:

To review the principles of NIR fluorescence molecular imaging technology.
To summarize the applications of NIR-I and NIR-II fluorescence-guided surgery in biomedical research.
To discuss current challenges and future directions in fluorescence imaging for surgical navigation.

Main Methods:

Review of fluorescence molecular imaging principles.

Keywords:

NIR-I NIR-II fluorescence imaging image-guided cancer surgeries surgical navigation tumor

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Summary of representative applications of NIR-I/II image-guided surgery.

Analysis of challenges and future perspectives in the field.

Main Results:

NIR fluorescence imaging, including NIR-I and NIR-II regions, provides high precision in identifying tumor margins.
Growing number of NIR fluorescence-guided surgeries are being performed on animal models and patients.
The technology leverages advantages such as deep tissue penetration and minimal light scattering.

Conclusions:

NIR fluorescence imaging is a valuable tool for image-guided cancer surgery.
Further improvements in fluorescence imaging are needed to enhance surgical treatment efficiency.
Continued research and development hold promise for advancing cancer treatment through improved surgical navigation.