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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Dermis
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Related Experiment Video

Updated: Oct 13, 2025

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Lichen Planus.

Katharina Boch¹, Ewan A Langan^1,2, Khalaf Kridin^3,4

¹Department of Dermatology, University of Lübeck, Lübeck, Germany.

Frontiers in Medicine

|November 18, 2021

Summary

Lichen planus (LP) is a T cell-mediated skin and mucosal disease. Novel treatments like Janus kinase inhibitors and biologics offer future hope for managing this condition.

Keywords:

T-cell mediated inflammation lichen planus skin disease treatment

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Last Updated: Oct 13, 2025

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

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Published on: August 9, 2024

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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

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Published on: May 16, 2025

Area of Science:

Immunodermatology
Pathology

Background:

Lichen planus (LP) is a T cell-mediated inflammatory condition affecting stratified squamous epithelia.
Histological hallmarks include lichenoid infiltrate and basal layer vacuolar degeneration.
LP presents in cutaneous, mucosal, and appendageal subtypes, occasionally affecting nails exclusively.

Purpose of the Study:

To review the understanding of Lichen Planus (LP).
To discuss current and emerging therapeutic strategies for LP.

Main Methods:

Review of clinical presentation and histological findings for LP diagnosis.
Analysis of current treatment modalities including corticosteroids and immunosuppressants.
Exploration of novel therapeutic targets such as Janus kinase inhibitors and biologics.

Main Results:

LP diagnosis relies on clinical and histological evidence.
Current treatments (corticosteroids, immunosuppressants) are often insufficient.
Emerging therapies like Janus kinase inhibitors and biologics show promise.

Conclusions:

Lichen planus presents diverse clinical and histological features.
Existing treatments have limitations, necessitating alternative approaches.
Janus kinase inhibitors and biologics are poised to transform LP management.