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Adrenergic-Angiogenic Crosstalk in Head and Neck Cancer: Mechanisms and Therapeutic Implications
Vui King Vincent-Chong1, Mukund Seshadri1,2
1Center for Oral Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Abstract:
Head and neck squamous cell carcinomas (HNSCC) are loco-regionally aggressive tumors that often lead to debilitating changes in appearance, speech, swallowing and respiratory function in patients. It is therefore critical to develop novel targeted treatment strategies that can effectively target multiple components within the tumor microenvironment. In this regard, there has been an increased recognition of the role of neural signaling networks as mediators of disease progression in HNSCC. Here, we summarize the current knowledge on the mechanisms of adrenergic signaling in HNSCC specifically focusing on neurovascular crosstalk and the potential of targeting the adrenergic-angiogenic axis through repurposing of FDA-approved drugs against HNSCC.
Insights
Targeting neural signaling in head and neck squamous cell carcinomas (HNSCC) offers new treatment avenues. This study explores adrenergic signaling and neurovascular crosstalk for potential drug repurposing in HNSCC therapy.
Area of Science:
- Oncology
- Cancer Biology
- Neuroscience
Background:
- Head and neck squamous cell carcinomas (HNSCC) are aggressive tumors impacting patient quality of life.
- Tumor microenvironment and neural signaling play critical roles in HNSCC progression.
- Targeting multiple tumor components is essential for novel therapeutic strategies.
Purpose of the Study:
- To summarize current knowledge on adrenergic signaling mechanisms in HNSCC.
- To focus on neurovascular crosstalk and its role in HNSCC.
- To explore the potential of targeting the adrenergic-angiogenic axis for HNSCC treatment.
Main Methods:
- Review of current literature on neural signaling in HNSCC.
- Analysis of mechanisms involving adrenergic signaling pathways.
- Investigation of neurovascular crosstalk in the tumor microenvironment.
- Exploration of FDA-approved drug repurposing for targeting the adrenergic-angiogenic axis.
Main Results:
- Adrenergic signaling is increasingly recognized as a mediator of HNSCC progression.
- Neurovascular crosstalk is a significant component of the HNSCC microenvironment.
- The adrenergic-angiogenic axis presents a potential therapeutic target.
Conclusions:
- Understanding adrenergic signaling in HNSCC is crucial for developing targeted therapies.
- Targeting neurovascular crosstalk via the adrenergic-angiogenic axis shows promise.
- Repurposing existing FDA-approved drugs could offer effective treatment options for HNSCC.
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