Consensus core clinical data elements for meningiomas (v2021.1).

Area of Science:

• Neuro-oncology
• Genomics
• Clinical Data Management

Background:

• Increasing molecular analyses of meningiomas necessitate standardized clinical data collection.
• Harmonizing language across institutions is crucial for linking molecular alterations to clinical variables.
• The International Consortium on Meningiomas addresses this need for comparative and pooled analyses.

Purpose of the Study:

• To present a set of core and supplemental meningioma-specific common data elements (CDEs).
• To facilitate comparative and pooled analyses of meningioma molecular and clinical data.
• To establish a common language for neuro-oncology research.

Main Methods:

• Followed a 4-phase process: discovery, internal validation, external validation, and distribution.
• Organized CDEs into patient- and tumor-level modules.
• Defined and described 17 core (10 patient, 7 tumor) and 14 supplemental (7 patient, 7 tumor) CDEs.

Main Results:

• Developed a comprehensive set of meningioma-specific CDEs.
• 17 core CDEs and 14 supplemental CDEs were defined.
• CDEs are now publicly available for adoption.

Conclusions:

• CDEs provide a framework for data-sharing and collaborative research in neuro-oncology.
• Facilitates a common language for comparative and pooled meningioma analyses.
• Meningioma-specific CDEs are dynamic and open to international feedback for refinement.